Oncology: Unleashing One Human Scourge Against Another Pathology: CMV Stealth Tactics Health Policy: Report Redefines Medicare Payments Cancer Prevention: Seizing a Teachable Moment to Decrease Patient's Colorectal Cancer Risk Toxicology: Chip Data Show Genetic Ups and Downs Missing Piece in Biological Clock Discovered Cancer Trigger Must Remain Pulled for Melanoma to Develop Asthma Clues from the Mouths of Babes Bosnian War Refugees Disabled by Psychiatric Disorders Local Hospitals Fare Well in U.S. News and World Report Poll Best-Kept Secret of the Lab: Few Things Go as Planned Front Page

Appointments to Full and Endowed Professorships These faculty members were appointed to a full professorship in June. Hugh Auchincloss Jr. Professor of Surgery Massachusetts General Hospital Auchincloss is surgical director of pancreas transplantation at Massachusetts General Hospital and surgical director of kidney transplantation at Brigham and Women's Hospital. He is also director of the Juvenile Diabetes Foundation Center for Islet Cell Transplantation at HMS, launched last year. The center is a collaborative effort involving more than 30 scientists, representing six HMS-affiliated institutions. Their common purpose is to find a cure for Type I diabetes through islet replacement therapy. Auchincloss is interested in the mechanisms and control of allogeneic and xenogeneic graft rejection and tolerance induction. Peter Banks Professor of Medicine Brigham and Women's Hospital Banks is director of the Clinical Gastroenterology Service and the Center for Pancreatic Diseases at Brigham and Women's Hospital. His current clinical research centers on markers of severity in acute pancreatitis, its treatment, and newer methods of treating pain associated with chronic pancreatitis. David Blumenthal Professor of Medicine and of Health Care Policy Massachusetts General Hospital and Harvard Medical School Blumenthal is director of the Institute for Health Policy at Massachusetts General Hospital and Partners HealthCare. His research interests include the future of academic health centers, academic industry relationships in the life sciences, and quality management in health care. Donald Ingber Professor of Pathology Children's Hospital Ingber's research focuses on the importance of cell architecture and mechanical forces for the control of cell growth, viability, and function during angiogenesis. In his work, he has integrated approaches from molecular cell biology, engineering, and chemistry to more fully define the structural basis of cell and tissue regulation by the extracellular matrix. Ingber also has made major contributions to the fields of integrin signaling, tissue engineering, and tumor angiogenesis, including discovery of TNP-470, an anticancer drug that is currently in human clinical trials. Tomas Kirchhausen Professor of Cell Biology Center for Blood Research Kirchhausen's research focuses on the processes that mediate and regulate the movement of membrane proteins throughout cells. In particular, he studies the molecular mechanisms that underlie the cell's sorting machinery responsible for receptor-mediated endocytosis and secretion. He also studies protein networks, their regulation and signal integration that link the spatial organization of the cortical cytoskeleton with cell migration and growth, antigen presentation, and vesicular traffic. David M. Nathan Professor of Medicine Massachusetts General Hospital Nathan is director of the Diabetes Center and the General Clinical Research Center at Massachusetts General Hospital. His research focuses on the development, evaluation, and implementation of novel treatments for diabetes; epidemiologic studies of diabetes and its complications; and long-term trials with the aim of preventing diabetes and its complications. He currently chairs two NIH multicenter studies, the Diabetes Prevention Program and DCCT/EDIC study. Pablo Ros Professor of Radiology Brigham and Women's Hospital As chief operating officer for Partners Radiology, Ros oversees the Partners-wide radiology programs and the operations and planning of radiology at Brigham and Women's Hospital. His clinical expertise is in abdominal imaging with special interests in liver, pancreatic, and gastrointestinal radiology, particularly using computerized tomography and MRI. His research centers on liver-specific MRI contrast agents and radiologic­pathologic correlations in neoplasms. His recent MPH in health policy and management from HSPH has broadened his interest to health services research in radiology, such as mergers of academic departments, incentive plans, and radiology network development. Bruce Rosen Professor of Radiology Massachusetts General Hospital Rosen is director of the NMR Center in the Department of Radiology at Massachusetts General Hospital. His primary fields of research include the development and application of novel functional imaging tools to the study of the brain and heart, including magnetic resonance imaging, electromagnetic source imaging, and optical imaging. Rosen also has an adjunct appointment in the Nuclear Engineering Department at MIT, where he is involved in the Radiological Sciences Training Program. This full professor was appointed to an endowed chair in June. Stephen Marks François-Xavier Bagnoud Professor of Health and Human Rights Harvard School of Public Health Marks was director of the United Nations Studies Program at Columbia University and codirector of Human Rights and Humanitarian Affairs at Columbia's School of International and Public Affairs. As director of the François-Xavier Bagnoud Center at HSPH, he will expand faculty, teaching, and research on health and human rights issues in relation to communicable diseases, gender and reproductive rights, humanitarian emergencies, international standards, and sustainable development. His own research deals with human rights theory and practice in the context of the international political and legal system. Honors and Advances * A Runyon-Winchell fellowship has been awarded to HMS research fellow in pathology Eva Gordon. The postdoctoral fellowship is for three years and is given to outstanding young scientists conducting theoretical and experimental research relevant to the study of cancer. Gordon will conduct her research, "Exploring the Role of Deglycosylation in Protein Degradation," in the laboratory of Hidde Ploegh, the Edward Mallinckrodt Jr. professor of immunopathology. * The American Diabetes Association honored Lloyd M. Aiello, associate clinical professor of ophthalmology at Joslin Diabetes Center, with the 1999 Outstanding Physician Clinician in Diabetes Award at its annual meeting in June. Aiello, director of Joslin's William P. Beetham Eye Institute, is one of the pioneers of laser photocoagulation, a highly successful treatment for diabetic retinopathy. * The Society of Nuclear Medicine named S. James Adelstein, the Daniel C. Tosteson University Professor at Harvard and professor of radiology at Brigham and Women's Hospital, as the recipient of the Georg de Hevesy Award. Adelstein was honored with the award at the society's annual meeting for his pioneering use of radionuclides for cancer therapy. * Morris White, Howard Hughes Medical Institute associate investigator and HMS associate professor of biological chemistry in the Department of Medicine, received the Lilly Award for Outstanding Scientific Achievement from the American Diabetes Association. White, senior investigator in cellular and molecular physiology at Joslin Diabetes Center, was honored as the outstanding diabetes researcher younger than 45. He delivered the Lilly lecture, "From a Band on a Gel to the Beta Cell: The Story of Insulin Action," at the association's annual meeting in San Diego. * Instructor in anesthesia at Brigham and Women's Hospital Frederick Van Pelt has been named the 1999­2000 Deland fellow. The Deland Fellowship Program in Health Care and Society provides training in hospital administration to outstanding future health care leaders. As a fellow, Van Pelt will concentrate on patient satisfaction. * Research to Prevent Blindness has chosen Francesca Pignoni, assistant professor of ophthalmology (genetics) at Massachusetts Eye and Ear Infirmary, to receive a $165,000 Career Development Award. * Two HMS researchers at McLean Hospital, William Carlezon, assistant professor of psychiatry, and Yong Ke, instructor in psychiatry, have been awarded 1999 Young Investigator grants by the National Alliance for Research on Schizophrenia and Depression. The two-year, $60,000 awards will help fund research on the causes and possible treatments of these diseases. * Frederick Li, professor of medicine and vice chair for population sciences in the Department of Adult Oncology at the Dana­Farber Cancer Institute, will be awarded the American Cancer Society's highest honor at its annual meeting in November. Li will receive the 1999 Medal of Honor in Clinical Research for his outstanding contributions in clinical science. * HMS assistant professor of medicine (biostatistics) at Brigham and Women's Hospital Mei-Ling Ting Lee has been named a fellow of the American Statistical Association. Lee was honored at a ceremony held this past week in Baltimore at the joint statistical meetings for his influential contributions in statistical applications in the fields of microbiology and medical research. F Local Hospitals Fare Well in U.S. News and World Report Poll U.S. News and World Report recently released its annual guide to America's best hospitals, with Massachusetts General Hospital and Brigham and Women's Hospital selected as being among the top hospitals in the country. Both hospitals made it onto the U.S. News honor roll, a list of 13 hospitals that ranked high in several specialties. MGH was third while BWH was eighth on the list. HMS-affiliated hospitals fared well in the 16 specialties rated by the magazine. Children's Hospital was ranked first for pediatrics, McLean Hospital was third for psychiatry, Spaulding Rehabilitation Hospital was thirteenth for rehabilitation, and Massachusetts Eye and Ear Infirmary was third for otolaryngology and fourth for ophthalmology. Beth Israel Deaconess ranked number 17 in cardiology, 12 in endocrinology, 19 in gastroenterology, 8 in geriatrics, 39 in gynecology, 44 in neurology, 50 in otolaryngology, 24 in pulmonary disease, and 24 in urology. Brigham and Women's ranked number 39 in cancer, 4 in cardiology, 6 in endocrinology, 10 in gastroenterology, 15 in geriatrics, 4 in gynecology, 13 in neurology, 9 in orthopedics, 49 in otolaryngology, 7 in pulmonary disease, 4 in rheumatology, and 25 in urology. MGH ranked number 18 in cancer, 3 in cardiology, 2 in endocrinology, 4 in gastroenterology, 5 in geriatrics, 6 in gynecology, 2 in neurology, 4 in ophthalmology, and 3 in orthopedics.