Pathology: Cells Prove to Have Strong Response To Their Physical Environment Biological Chemistry: The Ins and Outs of Making a Ribosome Education: Introducing the Class of 2003 Outreach: HMS and Boston Schools Join Forces Ambulatory Care: Understanding Cultural Differences Helps Doctors Give Better Care Agent May Be Effective Against Vascular Inflammation Studies Illuminate Heparin's Role in the Body Anticancer Gene May Work by Controlling Cell Death Social Interaction in Later Years May Delay Cognitive Decline Dyson Professorship Established Honors and Advances News Briefs In Memoriam: Chilton Crane Olive Gates Louis Diamond When East Meets West in Medicine Front Page

In a ceremony held July 19, the Margaret M. Dyson professorship in pediatric oncology was formally established, and Steven Burakoff (far right), professor of pediatrics at the Dana–Farber Cancer Institute, was named the first Dyson professor. Burakoff, chair of the Department of Pediatric Oncology and the first Ted Williams senior investigator at Dana–Farber, is known worldwide for his studies of the immune system and improving bone marrow transplantation. The endowed professorship is named for one of the founders of the Dyson Foundation, which has been a longtime supporter of pediatric care and research at Dana–Farber. With Burakoff above are (l to r) CEO of Dana–Farber David Nathan, president of the Dyson Foundation Anne Dyson, and Dean Joseph B. Martin. Honors and Advances * The American Neurological Association has selected Christopher A. Walsh, associate professor of neurology at Beth Israel Deaconness and director of the the hospital's Division of Neurogenetics, as the recipient of the Derek Denny-Brown Neurological Scholar Award. The award is given to a new member who has made major contributions in neurological research and who shows continued promise. * The National Institute of Mental Health has awarded a five-year, $1 million research grant to Martin Teicher, HMS associate professor of psychiatry at McLean Hospital. Director of the Developmental Biopsychiatry Research Program at McLean, Teicher will continue his research into the underlying mechanisms of adolescent brain development. His work is expected to provide insight into schizophrenia, attention deficit–hyperactivity disorder, and Tourette's syndrome, three major illnesses believed to arise from errors that occur during development. * Debabrata Mukhopadhyay, assistant professor of pathology at Beth Israel Deaconess, received the 1999 Eugene P. Schonfeld Young Researcher's Award from the Kidney Cancer Foundation. The two-year, $60,000 award is given to a promising young researcher in kidney cancer, and will be used by Mukhopadhyay to investigate the regulation of angiogenesis and tumor growth and to explore a novel therapy for human renal tumors in a mouse model. * One of the first Maurice E. Mueller Prizes for Excellence in Orthopedic Surgery will be awarded to William Harris, the Alan Gerry clinical professor of orthopedic surgery and director of the Adult Reconstructive Unit of the Orthopedic Service of Partners HealthCare System at Massachusetts General Hospital. The award, given for lifetime achievement in the field, will be presented by the president of the Swiss Orthopedic Society at a ceremony to be held in Switzerland later this month. * The National Alliance for Research on Schizophrenia and Depression has awarded Andrew Stoll, assistant professor of psychiatry and director of the psychopharmacology research lab at McLean, the 1999 Klerman Award. Stoll was recognized for his research, published in the Archives of General Psychiatry, on the short-term benefits of omega-3 fatty acids for patients with manic depression. News Briefs * Applications are being accepted for the 2000 Harvard Macy Institute Program for Physician Educators, which gives physicians an introduction to educational theory and practice and prepares them to take leadership roles in educational activities at their institutions. Several positions are reserved specifically for Harvard faculty and include a full tuition waiver. The application deadline is September 7. For more information, contact Elizabeth Armstrong at 432-0340. * In July, Belmont voters approved a plan to rezone land owned by McLean Hospital. After three years of negotiations between the town and the hospital, the plan will allow McLean to build a senior community, clustered townhouse units, and a research and development complex. It also calls for the preservation of 141 acres of open space, as well as historic buildings. * In other news at McLean Hospital, an agreement has been made between the hospital and the Massachusetts Department of Social Services (DSS) for McLean to provide transitional services to children and adolescents in the greater Boston area who are in DSS custody. Under the agreement, McLean will expand its Acute Residential Treatment program in an attempt to provide more appropriate care to children in need of transitional services who would otherwise be relegated to inpatient psychiatric units. In Memoriam Former HMS clinical professor of surgery Chilton Crane died at the age of 88 on August 2. Born in Richmond, Mass., he graduated from HMS in 1938. Crane received two Bronze Stars during World War II, serving in the Army as commander of the Fifth Portable Surgical Hospital in the Pacific theater. Following the war, he joined the staffs of Brigham and Women's Hospital and the West Roxbury Veterans Administration Medical Center, where he was chief of vascular surgery and chief of surgical service for 40 years until his retirement in 1987. Crane was also the former president of the Massachusetts chapter of the American College of Surgeons and vice president of the New England and Boston surgical societies. He is survived by his wife, Louise; a son, Nathaniel of Tuftonboro, N.H.; four daughters, Mary of Dover, N.H., Elizabeth of Scottsdale, Ariz., Anne Kirby of Brookline, and Sarah Chandler of Sterling; two sisters, Caroline Crane and Elizabeth Schlosberg, both of Providence, R.I.; and six grandchildren. Olive Gates, former HMS clinical professor of pathology, died July 13 at the age of 98. Gates was born in Worcester and graduated from Vassar College and Yale School of Medicine. She taught for 30 years at HMS, and was a cancer pathologist at the Cancer Research Institute at Deaconess Hospital, where she performed clinical work and conducted research on the effects of radiation on human cancer. She was also a consulting pathologist at Palmer Memorial Hospital and the Westfield State Sanitorium. In 1958, Gates became the first woman to be honored with a gold medal for distinguished service by the Massachusetts chapter of the American Cancer Society. Louis Diamond, known to many as the father of pediatric hematology and internationally recognized for his pioneering work in the treatment of newborns with Rh disease, died June 14. He was 97. The HMS emeritus professor of pediatrics and former associate chief of staff at Children's Hospital, was born in the Ukraine and educated at Harvard University and HMS, where he remained for more than 40 years. Diamond and Kenneth Blackfan, former HMS professor of pediatrics, identified Rh disease in 1932, a disorder that affected 1 in 200 infants at the time, as the source of what was previously thought to be four separate infant diseases. Rh-negative mothers carrying a fetus with Rh-positive blood produce antibodies against their child's blood, which damage the red blood cells and cause severe anemia, heart failure, and brain damage. The treatment for Rh disease was the wholesale replacement of blood in the newborn to eliminate the mother's antibodies and the damaged red blood cells, which took days to accomplish since a newborn's blood vessels are so small. In 1946, Diamond and former HMS assistant clinical professor of pediatrics Fred Allen began performing the transfusion through the umbilical vein, using newly created plastic tubing. Due to this method, called exchange transfusion, mortality from the disease soon was only a tenth of what it had once been. Even after an Rh disease vaccine had been discovered, the procedure continued to be used to treat infants. From 1948 to 1950, Diamond served as medical director of the American Red Cross's National Blood Program. Also in the late '40s, he established the Blood Grouping Laboratory in Boston. After retiring from HMS in 1968, Diamond taught at UCLA and UCSF, where the Louis K. Diamond chair of hematology is named in his honor. He leaves a son and daughter, Jared and Susan, both of Los Angeles; a sister, Sally Taft of Hershey, Pa.; and four grandchildren.