BIOLOGICAL CHEMISTRY
Researchers Glimpse Poliovirus as It Enters Host Cell
Images Could Shed Light on More Intractable Bugs
A team of researchers at HMS and other institutions has produced the first 3-D structuresthe biological equivalent of snapshotsof the poliovirus in the moments after it attaches to and enters a host cell. The structures, which appear in the February Journal of Virology, follow on the heels of a molecular rendering by the same team of the virus attaching to the host cell receptor. The virusreceptor complex was published in the Jan. 6 Proceedings of the National Academy of Sciences.
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