Perinatology: Introducing Baby to the Right Bacteria Nutrition: Macrophage Protein May Block Atherosclerosis Medicine: Breathing New Life into Asthma Therapy Genetics: Gene Found for Rare Bone Disorder Leadership: Lipsitz Named the Head of Division on Aging Minority Health: Symposium Seeks to Advance Multicultural Medicine Recognition: HMS and HSPH Professors Win GM Cancer Award New Books: Summer Bookshelf Medical Education: Shore to Lead Promotion and Review Board Dopamine Shown to Inhibit Growth Factor, Block Angiogenesis Embryo Research: To Ease Suffering or Do Nothing? Novel Structural Protein Discovered in Heart and Muscle On Road to Healthy Aging, Each Person Shares Controls Society of General Internal Medicine Presents HMS Professor with Glaser Award Mount Auburn Cited Among Nation's Top Hospitals for Intensive Care Braunwald to Receive Award at World Congress for Heart Research HMS Faculty Teaching Awards Honors and Advances Meeting Aims to Stir Up Solutions for Postdocs The Sacred Trust Beyond Patient and Doctor Call for Writers Front Page

NEW BOOKS The Summer Bookshelf Recent Books by Faculty from Harvard Medical, Dental, and Public Health Schools Lee Baer The Imp of the Mind: Exploring the Silent Epidemic of Obsessive Bad Thoughts Dutton Everyone has bad thoughts from time to time—an impulse to act out violently in public; an upsetting, unwanted sexual image; or even a blasphemous thought that imposes itself during a religious ceremony. For most, these occasional bad thoughts are nothing but a fleeting annoyance. For others, they can be debilitating. In the first book to explore fully the widespread problem of obsessive bad thoughts, Lee Baer, HMS associate professor of psychology at Massachusetts General Hospital, brings together the latest research and his own extensive experience treating this problem. Drawing on a wide variety of sources, from new advances in brain science to classic literature and history as well as hundreds of case studies from his own practice, Baer explores the causes of bad thoughts, why they can get out of control, and what to do when that happens. "If you follow the instructions given here, most of you will find some measure of relief from your bad thoughts," he writes in his conclusion. Richard Schwartz and Jacqueline Olds Marriage in Motion: The Natural Ebb and Flow of Lasting Relationships Perseus Publishing The husband and wife team of Richard Schwartz, HMS associate clinical professor of psychiatry, and Jacqueline Olds, HMS assistant clinical professor of psychiatry, both at McLean Hospital, assert that "there is no such thing as constancy in marriage." Instead, the partners in every marriage experience ever-shifting levels of closeness and intimacy. In their book, they tell how this natural "tidal drift" is healthy to an extent but can threaten the partnership if left unchecked. They describe the events, such as the birth and departure of children, death of parents, and career moves, that are often accompanied by changing patterns of intimacy. They outline the typical stages in marriage, offering suggestions for weathering these life events as well as for handling temptation and jealousy, dissatisfaction, and the prospect of divorce. Schwartz and Olds note that the discussion "applies equally well to all central adult relationships, including heterosexual and homosexual alliances, deep friendships, and other dyadic relationships." Michael J. Bennett The Empathic Healer: An Endangered Species? Academic Press Empathy has long been considered an important quality for doctors and especially psychotherapists. But current trends in medical practice often emphasize objectivity and standardized treatment of disease rather than personal care. As research uncovers the biological underpinnings of brain function, psychiatry has begun to focus on science rather than healing. In this book, Michael Bennett, HMS associate clinical professor of psychiatry at Beth Israel Deaconess Medical Center, argues for incorporating empathy into a discipline that has been changed by managed care. He discusses the history of empathy in medicine and its context in current theories of the brain. Drawing a distinction between treatment and healing, Bennett develops a model for psychotherapy within a system of care, recognizing the relationship between mind and brain. In his foreword, Roger Meyer writes, "Dr. Bennett has laid out a clinical practice paradigm to a field that is hungry for direction." Tracy Batchelor and Merit Cudkowicz, Editors Principles of Neuroepidemiology Butterworth–Heinemann This textbook, intended for interested clinicians and researchers in neurology and neurosurgery, provides both a review of the basic concepts of epidemiology and a discussion of the epidemiologic aspects of neurologic diseases. The first four chapters cover epidemiologic methods, statistics, clinical trial design, and measurement of health status. Chapters 5 to 16 focus on major neurologic diseases. Each disease-oriented chapter is divided into sections on descriptive and analytical epidemiology and clinical trials and intervention studies, including defining outcomes and cost effectiveness. Chapter topics include stroke, seizures, headache, back pain, brain injury, brain tumors, sleep disorders, neurogenetic disorders, motor neuron disorders, multiple sclerosis, and Alzheimer's and Parkinson's diseases. The book was written by 30 contributors, most from HMS and HSPH, and edited by Tracy Batchelor and Merit Cudkowicz, both HMS assistant professors of neurology at Massachusetts General Hospital. Graham A. Colditz and David Hunter, Editors Cancer Prevention, Vol. 1: The Causes and Prevention of Cancer Kluwer Academic Publishers This first volume in a series, produced by the Harvard Center for Cancer Prevention, is designed to give researchers, clinicians, and health policy workers an overview of current evidence of the causes of cancer and strategies to promote its prevention. As knowledge about the epidemiology and underlying causes of cancer becomes more sophisticated, it becomes crucial to find ways to communicate risk of cancer to the public and find prevention strategies. Edited by Graham Colditz and David Hunter, both HSPH professors of epidemiology, the book expands on previous reports from the center by summarizing what is known about cancer risk in the U.S. The second half of the book discusses the effects of prevention programs, educational campaigns, and public policy initiatives for preventing cancer. It offers a series of recommendations to help reduce cancer risk through diet and other behavioral changes. Kevin J. Donohoe and Annick D. Van den Abbeele, Editors Teaching Atlas of Nuclear Medicine Thieme This abundantly illustrated book is designed to provide clinicians with a guide to interpreting nuclear medicine images. Using the case study method, editors Kevin Donohoe and Annick Van den Abbeele and their contributors present a brief clinical description for each of 169 actual patients, followed by clinical images. Pertinent technical aspects of the images are provided next, followed by interpretation and diagnosis. Donohoe, HMS instructor in radiology at Beth Israel Deaconess Medical Center, and Van den Abbeele, HMS assistant professor of radiology at the Dana–Farber Cancer Institute, encourage the reader to approach the images as they would in a clinical situation. Studying the images, clinicians and other readers gain a deeper appreciation for the physiological effects of diseases such as sickle cell anemia, osteomyelitis, pulmonary embolisms, cardiomyopathy, AIDS, Alzheimer's disease, and cirrhosis, as well as most forms of cancer. "We hope to make the book challenging for the reader, and also fun," write the editors. Marc J. Kaufman, Editor Brain Imaging in Substance Abuse: Research, Clinical, and Forensic Applications Humana Press Until recently, little was known about how addictive substances affect the brain in humans. Beginning with positron emission tomography (PET) in the 1980s, researchers have been using new brain imaging techniques to study the effects of substance abuse on the structural and functional anatomy, biology, and chemistry of the brain. The goal of this edited volume is to describe the methods and review the research findings generated by methods such as electroencephalography, emission tomography, and magnetic resonance. "It is the consensus of the contributors to this volume that the most comprehensive view of the mechanisms and consequences of drug abuse and dependence will be achieved by those who can understand and synthesize the research findings from all these brain imaging modalities," writes editor Marc Kaufman, HMS assistant professor of psychiatry at McLean Hospital. C.H. Evans and P.D. Robbins, Editors Gene Therapy in Inflammatory Diseases Birkhäuser Verlag In what the editors call the first book to be dedicated to inflammation gene therapy, the contributing authors build a case for gene transfer technology to achieve "sustained, targeted, local production of therapeutic gene products" in treating chronic inflammatory diseases. A gene transfer approach to delivering therapeutic proteins and nucleic acids is desirable, the authors say, because of its promise to be longer acting and more specific than traditional drug delivery methods. The disorders addressed—which are difficult to treat and nearly impossible to cure—include rheumatoid arthritis, lupus, multiple sclerosis, Type I diabetes, and asthma. Editors Christopher Evans, a visiting professor of orthopedic surgery at Brigham and Women's Hospital, and Paul Robbins, of the University of Pittsburgh School of Medicine, based the content on authoritative reviews in each of the major disease areas. Hari G. Garg and Michael T. Longaker, Editors Scarless Wound Healing Marcel Dekker "Scarless healing in the skin is a subject of intense investigation in both academic and commercial research departments," the editors write in the preface. "Excellent progress has been made in wound healing but it is not currently possible to prevent repair defects."Aimed primarily at surgeons, particularly plastic surgeons, and dermatologists, this book covers developments in the wound repair process toward the as yet unattained goal of scarless wound healing. Edited by Hari Garg, HMS principal associate in medicine at Massachusetts General Hospital, and Michael Longaker from the NYU School of Medicine, the book's 15 chapters (some written by HMS faculty) discuss the chemistry of scarring, the role of hyaluronan–receptor interactions in wound repair, recent advances in embryonic wound healing, and the clinical use of skin substitutes, among other topics. Scott Lee BrainChip for Microbiology Blackwell Science A review for the Step I U.S. Medical Licensing Examination in microbiology, this book is geared toward students preparing for the USMLE as well as clinicians looking for a broad overview of microbiology. The text, organized by microorganism group, covers only the essential information in microbiology, including basic science and clinical presentation of infectious diseases. Diagnosis mechanisms and treatment options also are presented, which are up to date with CDC guidelines for 2001. Descriptions in the book are illustrated with ample clinical photographs, many of which were taken by author Scott Lee, a recent HSPH graduate who did fieldwork in Thailand, Ecuador, the Philippines, and El Salvador. The book is meant to be used in conjunction with a standard text and class notes for a foundation in microbiology and added detail. JoAnn Manson and Patricia Amend The 30-Minute Fitness Solution: A Four-Step Plan for Women of All Ages Harvard University Press JoAnn Manson, HMS professor of medicine and chief of the Department of Preventive Medicine at Brigham and Women's Hospital, teamed up with journalist Patricia Amend to write this easy to follow fitness book for women. Emphasizing that it takes only 30 minutes a day to improve health and prevent some diseases and that new studies now dismiss the "no pain, no gain" exercise mentality, the authors have put together a four-step plan to help even the busiest, most tired, or "down" women find the time and energy to include physical activity in their schedules. There are special activity guidelines for women during and after pregnancy, as well as for those with health conditions like hypertension, diabetes, obesity, heart disease, osteoporosis, and arthritis. Nutritional information is also covered. "A major goal of this book is to make sure that women know that regular exercise is one of the best things they can do to prevent heart disease, stroke, diabetes, osteoporosis, some cancers, and other chronic diseases," Manson writes. Muriel R. Gillick Lifelines: Living Longer, Growing Frail, Taking Heart W.W. Norton and Company Life expectancy at birth is currently 74 years for American men and 78 years for women, with many people living significantly longer. Although most of these elders are enjoying longer health as well as longer life, many others are not, particularly people living into their 80s and 90s. Muriel Gillick, HMS associate professor of medicine at Beth Israel Deaconess Medical Center and an expert in elderly care, defines frailty as a condition where multiple physical or cognitive impairments and limited reserves make it difficult to function in daily life and leave the person vulnerable to serious complications from even minor illnesses. The book "seeks to help the frail elderly and their families cope with their condition by describing some of the most common causes of frailty and discussing the medical, ethical, and social issues they engender," she writes. To bring these issues to life, she weaves each chapter around the experiences of four composite patients drawn from her clinical work. John J. Ratey A User's Guide to the Brain Pantheon Books In his introduction to this book, author John Ratey, HMS associate clinical professor of psychiatry at the Massachusetts Mental Health Center, likens the discoveries in neuroscience today to Balboa's first look at the Pacific Ocean: "We don't yet know the full meaning of what we are seeing in the neurosciences, but we do know it means the beginning of a new age." Current research is beginning to tell us how the brain actually works, he says, and is tending to unite fields as diverse as anthropology, philosophy, linguistics, and psychology. Ratey's overarching goal is to explain to the lay reader, without jargon, the complexity of the brain's inner workings. He divides his subject into 10 chapters that strike major themes commonly associated with the brain such as perception, attention and consciousness, memory, and emotion. And he discusses at length the "four theaters" of the brain: perception; attention, consciousness, and cognition; function; and identity and behavior. Manohar M. Panjabi and Augustus White III Biomechanics in the Musculoskeletal System Churchill Livingstone Manohar Panjabi, professor of orthopedics and rehabilitation at Yale University, and Augustus White, HMS professor of orthopedic surgery at Beth Israel Deaconess Medical Center, have written a book that explains musculoskeletal biomechanics and their relevance to clinical practice, without relying on complex mathematics. An introductory chapter, intended as a refresher in basic mechanics, covers topics including scalars and vectors, coordinate systems, and basic trigonometric functions. Subsequent chapters deal with the motion of rigid bodies, materials and structures under loads, vibrations, and joint friction, wear, and lubrication. The final chapter describes the properties of materials, both natural (different types of bone, cartilage) and artificial (metals and alloys, polymers, bone cements). Abundant examples are drawn from both the clinical arena and elsewhere, and the volume is richly illustrated with hundreds of clear, simple diagrams. The material presented will help the reader "understand the mechanical basis of normal function, and of many musculoskeletal diseases, and their diagnoses and treatment modalities; evaluate and improve the known treatment procedures and develop new ones; and keep abreast of new biomechanical research findings...," the authors write. Alan Woolf, Margaret Kenna, and Howard Shane, Medical Editors The Children's Hospital Guide to Your Child's Health and Development Perseus Publishing This all-encompassing child health guide, written with the assistance of more than 75 physicians and other health experts from Children's Hospital, tracks physical and psychological development from prenatal life through adolescence. Part one covers pregnancy, birth, and perinatal issues. Part two treats developmental benchmarks, month-to-month and year-to-year. Part three offers help for parents in choosing and interacting with health care providers and insurance plans. Part four covers childhood illness in general, safety issues, and emergency treatment. The final section is a guide to common childhood illness, injury, and other conditions of concern. For each illness, the listing includes general facts, causes, signs and symptoms, prevention, and treatment options at home or in the care of a physician. Information boxes throughout the book describe the circumstances under which a doctor should be called. Medical editors of the volume are Alan Woolf, HMS associate professor of pediatrics; and Margaret Kenna and Howard Shane, both HMS associate professors of otology and laryngology. Jack Silversin and Mary Jane Kornacki Leading Physicians Through Change: How to Achieve and Sustain Results American College of Physician Executives Market forces have been changing the way health care delivery is organized and managed, and this change can be unwelcome for patients and physicians. Jack Silversin, HSDM assistant clinical professor of oral health policy and epidemiology, and co-author Mary Jane Kornacki are the cofounders of Amicus, a health care consulting firm in Cambridge. "Often we have observed that getting physicians to change looks a lot like the mythical Sisyphus rolling his rock uphill," they write. This book integrates their experiences working with leaders of health systems, physician organizations, and hospitals on developing better ways to handle change. It provides ways that an organization can build a foundation for change and outlines five change levers that can be used to implement new methods successfully. Sidebars throughout the book by more than 20 health care leaders highlight their experiences leading change. Steven M. Zeitels Atlas of Phonomicrosurgery and Other Endolaryngeal Procedures for Benign and Malignant Disease Thomson Learning Steven Zeitels, HMS associate professor of otology and laryngology, spent 10 years preparing this atlas, which includes photographs that not only show benign and malignant laryngeal pathologies, but also surgical procedures with instruments in the correct position. A leader in the field of laryngology, Zeitels, who is director of the Division of Laryngology and associate medical director of the voice laboratory at the Massachusetts Eye and Ear Infirmary, begins the book by providing a history of endoscopic surgery of the larynx and discussions of phonomicrosurgical management philosophy and instrumentation. Most of the rest of the book is dedicated to photographs that demonstrate state-of-the-art surgical procedures for different laryngeal pathologies, from polyps and cysts to vocal fold atypia/dysplasia and supraglottic cancer. This reference is a tool for students, residents, and practicing surgeons learning microsurgical procedures and any surgeon who operates on the vocal folds. Vladan Starcevic and Don R. Lipsitt, Editors Hypochondriasis: Modern Perspectives on an Ancient Malady Oxford University Press While hypochondriasis is considered a mental illness, its etiology and pathogenesis, as well as its treatment, have been debated for the last two centuries. This volume brings together essays by international experts representing diverse perspectives and covering the main schools of thought on the illness. Written primarily for practicing clinicians, including psychiatrists, psychiatric residents, clinical psychologists, and primary care physicians, it provides current information on epidemiology, clinical presentation, etiology and pathogenesis, diagnostic criteria and assessment, prognosis, and treatment. The book is edited by Vladan Starcevic of the University of Belgrade (Yugoslavia) School of Medicine and the University of Newcastle, Australia, and Don Lipsitt, HMS clinical professor of psychiatry at Mount Auburn Hospital. It includes essays by Lipsitt and Arthur Barsky, HMS professor of psychiatry at Brigham and Women's Hospital. Janet L. Abrahm A Physician's Guide to Pain and Symptom Management in Cancer Patients Johns Hopkins University Press "Despite extensive efforts to prevent cancer and find its cure, each year cancer causes hundreds of thousands of men and women to suffer," writes Janet Abrahm, HMS instructor in medicine at Brigham and Women's Hospital. Much of this suffering could be avoided if physicians were aware of the many approaches to relieving the pain—physical, psychological, and spiritual—associated with cancer. The first step for physicians is "to make the patient, not the disease, the focus of their attention, and anticipate patients' hidden concerns, answer their unasked questions, and help them deal with their fears," she writes. This requires two sets of skills—superior communication and technical expertise. The two-part structure of the book—Part I: Hidden Concerns, Unasked Questions and Part II: Pain Control and Symptom Management—reflects these dual requirements. Richard N. Wolman Thinking with Your Soul: Spiritual Intelligence and Why It Matters Harmony Books "This book is based on my belief that each of us possesses spiritual intelligence and that we have the capacity to think with our souls," writes the author. Using current theories of multiple intelligences as his springboard, Richard Wolman, who is an HMS assistant clinical professor of psychology at Cambridge Hospital, set out to evaluate the levels and areas of spirituality in people's lives. He developed the PsychoMatrix Spirituality Inventory (PSI), an 80-item inventory designed to assess the pattern of a person's spirituality. Using the PSI with more than 6,000 people, Wolman identified seven factors that make up human spiritual experience and behavior: divinity, mindfulness, intellectuality, community, extrasensory perception, childhood spirituality, and trauma. Studying their own PSIs, readers are encouraged to understand their spiritual makeup—strengths and limitations—which is crucial to being able to see and improve their personal relationships. Seeing patterns in their spirituality, they can change them if they choose.