Genomics: The Next Big Thing in Mining the Genome Women's Health: Communicating Breast Cancer Risk and Means of Prevention Oral Biology: The Mouth's Microbes Could Hold Clues to Early Cancer Detection Genetics: Rearrangement of DNA Shown to Cause Certain Lymphomas Structural Biology: Molecular Jumping Jack Shows Off Moves Minority Health: Drug Abuse and Bioterrorism Among Issues Raised by Minority Fellows The Summer Bookshelf: Recent Books by Faculty of HMS, HSDM, and HSPH Cloning Study Creates Tissues for Transplantation Heart Protection by Corticosteroids Bypasses Gene Regulation Anti-aging Mechanism Shown in Yeast, May Be Similar in People Proceedings of the HMS Faculty Council Actor Ford Named Global Environmental Citizen Portraits of HMS Women Faculty Leaders Unveiled Human Genome Chief Forecasts Blue Skies for Medical Genomics HOLLIS Gets New Look, Features Alpert Prize Winners Reveal Secrets of the Heart HMS Junior Faculty Receive Armenise Awards Biosecurity Conference Addresses Bioterrorism Threat Barger Speaker Urges Advocacy New Howard Hughes Investigators Chosen for Patient-oriented Research HMS Presents Faculty Awards Honors and Advances Where Have All the Surgeons Gone? Front Page

NEW BOOKS Kenneth Arndt and Kathryn Bowers Manual of Dermatologic Therapeutics, Sixth Edition Lippincott Williams & Wilkins Kenneth Arndt, HMS clinical professor of dermatology, and Kathryn Bowers, HMS assistant clinical professor of dermatology, both at Beth Israel Deaconess Medical Center, have updated this compact yet comprehensive manual for the sixth edition. It is composed of three sections: diagnosis and therapy of 36 common dermatologic diseases (for example, herpes simplex, keratoses, and skin cancer); operative procedures (such as biopsy and electrosurgery) and therapeutic techniques (such as cytologic smears and ultraviolet light therapy); and treatment priniciples and formulary. The appendices provide information on websites, foundations, institutes, and support groups. The book includes 48 color plates. Deirdre Barrett The Committee of Sleep: How Artists, Scientists, and Athletes Use Dreams for Creative Problem-solving--And How You Can Too Crown Publishers Taking its title from a John Steinbeck quote ("It is common experience that a problem difficult at night is resolved in the morning after the committee of sleep has worked on it"), this book details how Salvador Dali, Ingmar Bergman, Robert Altman, Billy Joel, Otto Loewi, and others have used their dreams to influence their work. Using anecdotes from the lives of artists, scientists, and athletes, Deirdre Barrett, an HMS assistant clinical professor of psychology in the Department of Psychiatry at Cambridge Hospital, shows how paying attention to dreams can help solve creative as well as everyday problems. Rose E. Frisch Female Fertility and the Body Fat Connection University of Chicago Press "Since the dawn of human history, the symbols of female fertility have been fat, very fat," writes Rose Frisch, HSPH associate professor emerita of population sciences, in the opening of her book. Did the ancients know something that has been forgotten in the current cultural obsession with pencil-thinness? Frisch's own research has shown that body fat and fertility are linked and that a certain amount of body fat is crucial to a woman's reproductive system and sexual maturation. In her book, she explores her theory and explains how and why a critical fatness level underlies women's reproductive health. She discusses questions such as What are the triggers that set off menstruation in girls? How can women lessen the risk of cancers of the reproductive system? Are girls entering puberty earlier than they used to? Michele J. Karel, Suzann Ogland-Hand, and Margaret Gatz, with Jürgen Unützer Assessing and Treating Late-life Depression: A Casebook and Resource Guide Basic Books Many factors can lead to depression in older adults--infirmity and illness, lack of access to affordable health care, decreasing independence, and tight household budgets. As the population ages, the number of people at risk for late-life depression is rapidly increasing. Something can be done--late-life depression is treatable, according to Michele J. Karel, HMS instructor in psychology in the Department of Psychiatry at the Brockton VA Medical Center, and her colleagues. Using 14 case studies, the authors explicate a range of syndromes and provide strategies for assessing and treating them. They conclude with a guide to medications, screening tools, innovative models, and supplementary resources. Frederic Shapiro Pediatric Orthopedic Deformities: Basic Science, Diagnosis, and Treatment Academic Press In three parts, this text covers skeletal development and the imaging methods to assess it, disorders of the developing hip and knee, and more complicated growth-related deformities. Frederic Shapiro, HMS associate professor of orthopedic surgery at Children's Hospital, describes the causes of pediatric deformities in the early interplay between pathobiology and normal bone biology and discusses their diagnosis and treatment. Many of these conditions become worse with growth, though some improve spontaneously or with intervention. Shapiro writes that the premise of the book is that treatment is always more effective if it is based on an understanding of a deformity's underlying biology. Eli Peli and Doron Peli Driving with Confidence: A Practical Guide to Driving with Low Vision World Scientific One of the realities of an aging population and a society that relies on motor vehicles is an increase in the number of drivers with low vision conditions on the road. People with low vision do not necessarily have to give up safe driving if they make smart choices, according to a book co-authored by Eli Peli, HMS associate professor of ophthalmology at Schepens Eye Research Institute and an expert on vision rehabilitation. Driving with Confidence, printed in large type and designed for a lay reader, gives practical advice on obtaining a low vision driver's license and understanding how to drive safely. The book guides the reader through the basic biology of vision, recent research on vision and driving, and the requirements of low vision driving tests. A questionnaire helps readers make an informed decision to drive or not. The book also recommends an approach to preparing for testing, and reviews available low-vision driving aids and vision requirements by state. Michael Reich, Editor Public-Private Partnerships for Public Health Harvard Center for Population and Development Studies This collection of essays (some written by faculty and doctoral students at the Business and Public Health schools) addresses the increasing number of partnerships between public and private enterprises tackling global health issues and the possible problems that may arise. The book examines the challenges--organizational and ethical--faced when private corporations and governments, international agencies, and nongovernmental organizations collaborate, specifically the differences in values, interests, and worldviews. The essays look at both successful and unsuccessful collaborations to determine what works when attempting to reduce global health disparities. The book is edited by Michael Reich, the Taro Takemi professor of international health policy at HSPH and director of the Harvard Center for Population and Development Studies. Michael Ronthal Gait Disorders Butterworth-Heinemann When an elderly person comes in with the complaint, "Doctor, I can't walk," a doctor can find a treatable disorder in about one in four cases. Despite new technologies, the basis of diagnosis and treatment of gait disorders rests on a meticulous clinical examination, writes Michael Ronthal, HMS associate professor of neurology at Beth Israel Deaconess Medical Center. Ronthal likens the examination to a detective story, eliminating a list of suspects one by one. For clinicians, "the trick is to consider the problem in terms of the most basic deficits rather than speculating about complex pathology," he writes. Eleven chapters in the book include an overview of physiology of gait, floor-scraping weakness in lower limbs, the stamping steps of proprioceptive loss, the staggering associated with cerebellar ataxia, involuntary movements stemming from dysfunction in deep brain structures, the curious stop and start of frontal lobe dysfunction, and psychogenic factors born of fear of falling and extreme caution. Eng H. Lo and Joe Marwah, Editors Neuroprotection Prominent Press Neuroscientists used to believe that damage to brain cells was irreversible. As they have learned more about how brain cells succumb to disease and injury at the molecular level, they have started looking for ways to protect and prolong the life of neurons. "The pessimism and nihilism accompanying discussions of neurological disorders have been replaced with a new optimism and energy," write Eng Lo, HMS associate professor of radiology at Massachusetts General Hospital, and Joe Marwah in the preface to this edited volume. In sections devoted to basic pathophysiology, acute central nervous system injury, and chronic central nervous system injury, a wide range of authors explore the cellular and molecular mechanisms of nerve cell damage, death, protection, and repair. "We hope that this volume will not only provide a state-of-the-art survey of this fast-moving and exciting field, but more importantly, present basic principles that can be revisited time and time again as new discoveries unfold," write the authors. Armand M. Nicholi Jr. The Question of God: C.S. Lewis and Sigmund Freud Debate God, Love, Sex, and the Meaning of Life The Free Press For more than 25 years, Armand Nicholi, HMS associate clinical professor of psychiatry at Massachusetts General Hospital, has taught a course at Harvard University comparing the worldviews of C.S. Lewis and Sigmund Freud, based on his research of their published and unpublished writing. This book draws its substance and insight from the course. Though Lewis and Freud never debated in the flesh, Nicholi has described their arguments side by side on many of the most profound issues of life: the existence of God, the pursuit of pleasure, the problem of suffering, and the nature of death. The author explains that since Lewis followed Freud's atheism for the first half of his life and then adopted a spiritual perspective, much of his defense of spirituality refutes Freud's arguments point by point. Nicholi is evenhanded in his treatment of both worldviews, leaving it to readers to form their own conclusions. Kimberly Thompson and Debra Fulghum Bruce Overkill: How Our Nation's Abuse of Antibiotics and Other Germ Killers Is Hurting Your Health and What You Can Do About It Rodale Overuse and misuse of antibiotics and other germ killers has backfired for people who continue to fear infection from harmful bacteria. Little do they know, a bigger fear is infection from harmful bacteria that have grown more difficult to kill. By some estimates, more than half the antibiotics in this country are used in agriculture, to fatten cattle for example. Yet human antibiotic abuse is believed to be the biggest contributor to the resistance problem. In their new book, Kimberly Thompson, HSPH assistant professor of risk analysis and decision science, and co-author health journalist Debra Bruce focus on the reader's personal risk factors for contracting germ-related illnesses. Page after page of self-help tips advise how to boost immunity, stay healthy, and reduce dependence on prescribed medications. In chapter two, the centerpiece of the book, 50 questions help people figure their risk for bacterial infections. Subsequent chapters advise on optimal health care, child care, home and work environments, and food preparation.