Immunology: Priming Cellular Pathway May Lead to New AIDS and Cancer Vaccines Structural Biology: Image of Epidemic Dengue Virus Reveals Drug Target Public Health: Common Industrial Ingredient Appears Able to Stifle Sperm Neurology: Alzheimer's Culprit Fingered as Gang of Four Immunology: New Vaccine Role Discovered for Anthrax Health Disparities: Minority Health Policy Program Points to Need for Dollars and Data AIDS Research: Advanced AIDS Research Facility to Open in South Africa in Collaboration with HMS New Books: The Summer Bookshelf   Rare Disease Offers Explanation of Ovarian Cancer's Drug Resistance High Colorectal Surgery Volume Tied to Better Outcomes Study Suggests Timely Control Efforts Can Halt Spread of SARS   Neuro Center Awards Innovation Grants Medical School Presents Faculty Teaching Awards New Chair in Women's Health Established at Brigham and Women's Hospital Delbanco Receives Glaser Award from the Society of General Internal Medicine HMS Faculty Named to American Academy of Arts and Sciences Alfred Sommers Wins Warren Alpert Prize HMS Faculty Council Reynolds Foundation Awards $24 Million for Heart Research at HMS and Brigham and Women's Hands-on Training Offered for GenBank and NCBI Molecular Resources Countway Redesigns Website CDC Warns of Squeeze on Disease Prevention Funds Honors and Advances Save the Date   Operation Mouthguard Protects Oral Health   Troubleshooting Allocation of Transplant Organs   Front Page

NEW BOOKS The Summer Bookshelf Recent Books by Faculty of Harvard Medical, Dental, and Public Health Schools Randy N. Rosier and Christopher H. Evans, Editors Molecular Biology in Orthopaedics American Academy of Orthopaedic Surgeons The capabilities of molecular biology have the potential to change the understanding and treatment of orthopedic diseases, but the first meeting to really address the issue was held recently--at a three-day workshop in 2001. Editors Randy Rosen, director of the Center for Musculoskeletal Research at the University of Rochester School of Medicine, and Christopher Evans, the Robert W. Lovett professor of orthopedic surgery at the Center for Molecular Orthopedics at HMS, say the workshop "revealed the degree to which molecular biology has become an integral part of modern orthopedic research." The proceedings of that event are published here; topics include recent findings in the development and molecular biology of bone and cartilage, insights into orthopedic diseases and cancers, and the potential for gene therapy to treat arthritis and bone diseases. Ann Aschengrau and George R. Seage III Essentials of Epidemiology in Public Health Jones and Bartlett This introductory epidemiology textbook cowritten by George Seage, an associate professor of epidemiology at HSPH, provides an update to traditional textbooks by incorporating the many changes and advances in the field during the past several years. Theories and methods of epidemiologic research have changed, and this text takes those changes into account. Four chapters are devoted to study design, including one each on experimental, cohort, and case-control studies, the latter having changed significantly. A chapter on causation includes a discussion of both the historical view on causation theories and more current models such as the sufficient/component model. And an entire chapter covers the concept of effect measure modification, typically overlooked in most introductory textbooks. Suzanne Bender and Edward Messner Becoming a Therapist: What Do I Say, and Why? Guilford Press Inspired by her own lack of confidence and experience as a newly minted psychiatrist, Suzanne Bender set out with her Massachusetts General Hospital mentor Edward Messner to write a practical guide to the practice of psychotherapy. The result is an enlightening and entertaining journey through the dilemmas that clinicians face when dealing with patients. Using case studies and dialogues, Bender, HMS clinical instructor in psychiatry at MGH, and Messner, HMS associate clinical professor of psychiatry, navigate a broad array of issues, such as setting up appointments with potential new patients, initiating the first session, collecting a psychosocial history, formulating a treatment plan, setting the fee, dealing with no-shows, coping with empathic lapses, transference, and termination. Barry R. Bloom and Paul-Henri Lambert, Editors The Vaccine Book Academic Press The Vaccine Book provides a soup-to-nuts overview of vaccines and immunization, examining their role in public health, the basic principles of immunology and pathology behind them, and the logistics, economics, and ethical considerations of bringing new vaccines to clinical trials. Several case studies also recount the development of vaccines for specific diseases, including polio, malaria, tuberculosis, and AIDS. Edited by HSPH dean Barry Bloom and Paul-Henri Lambert, professor of pathology at the University of Geneva, the book is aimed at students, health professionals, and interested lay readers who would like a broad understanding of immunization and its role in public health. Jonathan A. Edlow Bull's Eye: Unraveling the Medical Mystery of Lyme Disease Yale University Press Intrigued by reports of a strange new ailment afflicting some Connecticut residents, including his own relatives, Jonathan Edlow set out to learn more about the disorder that would come to be known as Lyme disease. More than 20 years later, Edlow, HMS assistant professor of medicine, has turned his interest into an engaging medical whodunit. In lively prose, he chronicles how connections were ultimately established between symptoms and tick bites, leading to a better understanding of the pathogenesis of the disease. Edlow, who is at Beth Israel Deaconess Medical Center, concludes by discussing the medical and social issues surrounding research and treatment of the disease. Fermin Carranza and Gerald Shklar History of Periodontology Quintessence Beginning with the prehistoric era and early civilizations in India, China, the Middle East, and pre-Columbian America and on through the Middle Ages and Modern Era through the end of the twentieth century, authors Carranza and Shklar trace the broad history of periodontology and the evolution of its concepts. The book ends with a chapter on the future of the specialty. "We have presented the landmark contributions to periodontics in relation to the basic sciences and clinical developments of the times and in the context of each period's social and political events," they write in the preface. Fermin Carranza is professor emeritus at the UCLA School of Dentistry, and Gerald Shklar is the Charles A. Brackett professor emeritus of oral pathology at HSDM. Hope Ricciotti and Vincent Connelly The Pregnancy Cookbook, Revised and Expanded W. W. Norton & Co. When Hope Ricciotti became pregnant with her second child, she was plagued by almost constant morning sickness. Unlike thousands of other women in her situation, Ricciotti happens to be an obstetrician and her husband happens to be a professional chef. Combining their expertise, and a heavy dose of ginger, they came up with a smoothie that essentially staved off the nausea. In this revised and expanded version of their earlier cookbook, Ricciotti, who is an HMS assistant professor of obstetrics, gynecology and reproductive biology at Beth Israel Deaconess Medical Center, and Connelly share their smoothie and other new time-saving recipes. They also incorporate current dietary restrictions concerning fish and cheese, tips for postpartum weight loss, and new findings about the importance of nutrition throughout the life cycle. Hope Ricciotti and Vincent Connelly The Breast Cancer Prevention Cookbook W. W. Norton & Co. "Many of us live in fear of developing breast cancer," write the authors in the beginning to this new book. And yet, they continue, women may have the power to save their own lives by educating themselves about screening and early detection methods and by making lifestyle and dietary changes. In the first half of this book, Hope Ricciotti and Vincent Connelly (see above) discuss how those changes can save lives. They provide nutritional guidelines for women, explain the role of phytoestrogens, exercise, and screening in preventing breast cancer, and discuss hormone replacement therapy, which Ricciotti no longer recommends to most patients. The fun begins in the second half of the book, which is packed with recipes for smoothies, soups, salads, pizzas, and calzones as well as vegetarian and non-vegetarian main dishes. Leonard S. Lilly, Editor Pathophysiology of Heart Disease: A Collaborative Project of Medical Students and Faculty, Third Edition Lippincott Williams & Wilkins Unlike most textbooks, this one is written not just for students but also, in part, by them. Leonard Lilly, HMS associate professor of medicine at Brigham and Women's Hospital, invited a group of HMS medical students to collaborate with him and other faculty members to produce a book that would, he writes, "meet the needs of medical students during their initial encounters with patients with heart disease." Now in its third edition, the book provides an introduction to the basic mechanisms underlying diseases of the cardiovascular system such as atherosclerosis, acute coronary syndromes, heart failure, hypertension, and many others. Remarkably concise, it is meant to be read cover-to-cover during the typically month-long course in cardiovascular pathophysiology. Leigh McCullough, Nat Kuhn, Stuart Andrews, Amelia Kaplan, Jonathan Wolf, and Cara Lanza Hurley Treating Affect Phobia: A Manual for Short-Term Dynamic Psychotherapy Guilford Press This book, aimed at teaching therapists how to do short-term dynamic psychotherapy (STDP), is based on the idea that much psychopathology is rooted in affect phobia--fear of feelings. Viewed this way, the well-established techniques and concepts of phobia treatment, such as systematic desensitization, can be brought to bear on psychodynamic issues in a way that helps to focus STDP and avoid common pitfalls. Among the authors are Leigh McCullough, an HMS associate clinical professor of psychology in the Department of Psychiatry at Beth Israel Deaconess Medical Center, and Nat Kuhn, an HMS clinical instructor in psychiatry at Cambridge Hospital. To help readers acquire the necessary skills, they include practical exercises at the end of each of the first 10 chapters. Martin Yarmush, Kenneth Diller, and Mehmet Toner, Editors Annual Review of Biomedical Engineering, Vol. 4 Annual Reviews Annual Reviews publishes analytic reviews in 29 disciplines covering the biomedical, physical, and social sciences. This, the latest volume in the biomedical engineering series, was edited by Martin Yarmush, the Helen Andrus Benedict professor of surgery (biological chemistry and molecular pharmacology) and Mehmet Toner, professor of surgery, both at HMS and Massachusetts General Hospital, with Kenneth Diller from the University of Texas at Austin. It contains reviews on a variety of technical topics including proteomics (co-authored by Yarmush), spine ergonomics, DNA microarrays, and bioluminescence imaging of gene expression. In addition, the volume includes a discussion of human safety issues involving electromagnetic fields and a review of advances in the role of learning sciences in biomedical engineering education. Martin Yarmush, Mehmet Toner, Robert Plonsey, and Joseph Bronzino, Editors Biotechnology for Biomedical Engineers CRC Press Martin Yarmush and Mehmet Toner (see above) are co-editors, with Robert Plonsey of Duke University and Joseph Bronzino of Trinity College, Hartford, Conn., of this new volume in CRC's Principles and Applications in Engineering series. It covers the topics in biotechnology of interest to the practicing biomedical engineer. These include protein engineering, monoclonal antibody production, applications of nucleic acid chemistry, applied virology, and cell structure and function. Beginning with an overview of the human physiologic systems, the book includes coverage of antisense technology with emphasis on basic techniques and potential applications to AIDS and cancer, and identifies the computational, chemical, and machine tools being developed and refined for genome analysis.