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Endocrinology:
Leptin Serves Body as Energy Signal
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Immunology: A Mechanism Discovered for Antibody Deployment
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Pathology: Tumor Suppressor Shows Another Way to Get Job Done
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Health Disparities: Symposium Explores Reasons and Remedies for Health Care Disparities
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Discovery Rewrites Text on Tendon Development
P53 Relative May Confer Sensitivity to Cancer Drugs
Targets Found in Worm Insulin Signaling
Study Suggests Hypnosis May Benefit Wound Healing
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Cambridge Health Alliance Names New CEO
Howard Koh Urges Political Action in Public Health
Alumni Week Preview
New HMS Registrar Announced
News Brief
In Memoriam:
Albert DeFriez
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 Students, Faculty Aid Refugee Families
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 Crossing Cultural Barriers a Patient at a Time
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BULLETINCambridge Health Alliance Names New CEO

Dennis Keefe
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Cambridge Health Alliance, an academic public health care system with three hospitals in Cambridge, Somerville, and Everett, has named Dennis Keefe as its new CEO. Keefe will also serve as commissioner of health for the City of Cambridge. He replaces John O'Brien, who left in September after serving as CEO for 16 years. Keefe's appointment culminates an extensive national search. He was part of the senior leadership team of HMS-affiliated Cambridge Hospital from 1986 to 1988. Then after holding key leadership positions at Morton Hospital and Medical Center in Taunton for 12 years, he returned to the alliance as chief operating officer in 2000. He has served as acting CEO for the past six months. Keefe is a summa cum laude graduate of Northeastern University. As a faculty member there, he went on to receive his MBA with a concentration in Health Care Administration. "Harvard Medical School faculty based at the alliance's Cambridge Hospital are an integral part of the teaching and research mission of the School," said HMS dean Joseph Martin. "Keefe's willingness to partner with the Medical School will help bring our combined missions forward."
Howard Koh Urges Political Action in Public Health

Howard Koh Photo by Suzanne Camarata
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With a mix of diplomacy and activism, Howard Koh presented the 10th annual Alonzo Smythe Yerby Award Lecture at HSPH, calling on colleagues and students to become more politically engaged. "We public health folk spend too much time talking about public health with each other," he said in the April 10 talk. "If we really want to make a difference, we have to jump into the political realm and interact with the main players who don't know very much about public health and may not care very much about public health." Koh might have been reading a page from his own biography. A professor and skin cancer specialist at Boston University School of Medicine, School of Public Health, and Medical Center, he was appointed by Governor William Weld in 1997 to be the Massachusetts commissioner of public health. In that position he was a champion of disease prevention, serving the state until this year, when he came to HSPH as the associate dean for public health practice and a professor of health policy and management. He officially began on April 15. In his Yerby lecture, Koh culminated by defining what public health practice is: "Translating research into action and translating public health dreams into reality." The Yerby award and lecture honor the late Alonzo Smythe Yerby, who was an HSPH faculty member from 1966 to 1982 and the School's first African-American dean and department chair.
Alumni Week PreviewThis year Alumni Week runs from Wednesday, June 4, to Sunday, June 8. Some of the HMS events include: Wednesday, June 4 Division of Medical Sciences- sponsored alumni symposium on neurosciences, "New Disease Therapies: The Role of Biotechnology" Thursday, June 5 HMS Faculty Symposium, "Technology in Medical Education and Practice," moderated by Daniel Federman, senior dean for alumni relations and clinical teaching, and featuring panelists John Halamka, chief information officer and associate dean of educational technology at HMS; John Parrish, director of the Center for Integration of Medicine and Innovative Technology; Peter McLaren Black, neurosurgeon in chief at Brigham and Women's and Children's hospitals and chief of neurosurgical oncology at the Dana-Farber Cancer Institute; and David Altshuler, HMS assistant professor of genetics at Massachusetts General Hospital Keynote address at the Class Day degree ceremony by Paul Farmer, the Maude and Lillian Presley professor of social medicine Educational Technology open house Class of 1978 Symposium with panels on fixing the health care system, plagues and public health challenges, new pathways, and survival skills Friday, June 6 Alumni Day Symposium, "Small Pox: Proxy and Probe," with Kathleen Toomey, HMS '78, director of the Division of Public Health for Georgia's Department of Human Resources; Allan Brandt, the Amalie Moses Kass professor of the history of medicine at HMS; Kenneth Shine, HMS '61, senior policy fellow and director of the RAND Center for Domestic and International Health Security; and moderated by Daniel Federman, HMS '53 and senior dean for alumni relations and clinical teaching at HMS Tours of Countway Library For more information on these and other events and to register, visit www.hms.harvard.edu/alumni/week2003.htm or call 617-432-1560.
New HMS Registrar Announced

Terese Galuszka Photo by Liza Green, HMS Media Services
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Terri Orr, HMS associate dean for admissions and student services, announced the appointment of Terese Galuszka as the School's new registrar. Galuszka comes to HMS after serving nearly 10 years as registrar at the Massachusetts College of Pharmacy and Health Sciences, where she had also worked in admissions. Prior to the 19 years she spent at the College of Pharmacy, she worked for several years at the Greater Lowell Area Health Education Center. Galuszka holds an MS in health administration from the University of Colorado School of Health Sciences. She began in her new position on April 14 and can be reached in the Registrar's Office at 617-432-1515.
News BriefThe NIH-supported Clinical Nutrition Research Center at Harvard is accepting applications for new pilot feasibility projects as well as for competing renewals of currently funded one-year projects. Preference will go to young investigators involved in clinical research but without NIH grant support; established scientists not currently focused on nutrition who wish to initiate nutritional studies; and established nutrition researchers with novel new projects. The deadline is May 16. Contact Suzette McCarron at 617-726-4166 or e-mail smccarron@partners.org for an application.
In Memoriam

Photo by Samuel Cooper
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Albert DeFriez, retired HMS lecturer on medicine, died April 12 at the age of 85.DeFriez received his AB from Princeton in 1940 and his MD from Columbia in 1943. He interned at Bellevue Hospital in 1944 and served as a member of the medical corps of the U.S. Army assigned to the Air Force, from 1944 to 1946. He was a postdoctoral fellow in the laboratory of Eugene Landis in the Department of Physiology at HMS from 1947 to 1948, before joining the HMS faculty in 1949. His service and dedication to the Medical School and clinical community continued for more than 50 years. For many years, DeFriez practiced general internal medicine as a member of the HMS-affiliated Department of Medicine at New England Deaconess Hospital, where he was chairman of the general staff from 1975 to 1978, and chief of the primary care section from 1976 to 1984. He taught in several HMS courses and sat on the admissions committee. He retired from HMS in 1996.
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