Neurology: Compound Traces Brain Plaques in Real Time State of the School: HMS Dean Recaps Extraordinary Year Infrastructure: The New Research Building: A Towering Investment in Science Milestone Symposia: Symposium Highlights Molecular Architecture and Cellular Function Immunology: Innate Signal Sparks Homing of T Cells Awards: Two from HMS Among MacArthur Fellows New Books: The Autumn Bookshelf Improved Procurement Could More than Double Availability of Transplantable Organs Shifts in Training Needed to Care for Elderly Population World Smoking Deaths in a Year Estimated at 5 Million Blocking Exit from Cell Seen to Stifle HIV   HSPH Program Created for Environmental Risk Academy at HMS Announces New Fellows On the Move Judge Baker Groundbreaking CBR Transforms itself at 50 Honors and Advances News Brief In Memoriam: Thomas Fitzpatrick Claude Villee   H.E.A.L.T.H. NOW! Spells Health Education and Literacy   Vaccines: Who Should Pay and for What?   Front Page

NEW BOOKS The Autumn Bookshelf Recent Books by Faculty of Harvard Medical, Dental, and Public Health Schools Arthur Skarin, Editor Atlas of Diagnostic Oncology, Third Edition Mosby The third edition of this standard reference, edited by Arthur Skarin, HMS associate professor of medicine at the Dana-Farber Cancer Institute, continues to stand out for its focus on visuals, including photos, X-rays, and scan images. The summary text updates the histology, staging, and clinical manifestations of tumors, reflecting recent advances in radiographic and molecular diagnosis of disease. The 38 authors are past or present HMS faculty, more than half with appointments at Dana-Farber and the rest at Brigham and Women's Hospital and Children's Hospital. A pocket inside the front cover contains a CD-ROM of all the figures, tables, and charts for convenient use in lectures and presentations. Alexander Irwin, Joyce Millen, and Dorothy Fallows Global AIDS: Myths and Facts: Tools for Fighting the AIDS Pandemic South End Press Authors Alexander Irwin, Joyce Millen (an HMS research fellow in social medicine), and Dorothy Fallows explain why wealthy countries like the United States have a stake in fighting the AIDS pandemic in Africa and South America. The book is divided into three sections. The first, on "HIV/AIDS Basics," is a primer on AIDS terms and the disease itself. The second and largest focuses on 10 widespread misconceptions in wealthy countries about AIDS and the developing world. These include the notion that developing countries are too corrupt to responsibly distribute drug therapies and that there is nothing for the U.S. to gain from helping other countries battle AIDS. In the final section, the authors provide a list of organizations and resources for those who want to become involved in the global effort against AIDS. William C. Hsu and George L. King Staying Healthy with Diabetes: A Guide for the Chinese American Community Joslin Diabetes Center Diabetes is on the rise among Asian Americans, with type 2 diabetes five to seven times higher among Chinese Americans than in China. To help this growing population identify and live with diabetes, William Hsu and George King wrote a handy book, full of information, meal plans, and advice, such as which dishes to avoid at dim sum. Both men are HMS faculty members at Joslin Diabetes Center, Hsu an instructor in medicine and King a professor of medicine. The book's meal plans, geared toward a Chinese-American population, include a four-page section on Chinese foods with bits of information like the equivalence of one moo shu pancake with one serving of carbohydrates. The guide appears in English and Chinese and has colorful, light-hearted illustrations, making the text even more palatable. James A. Chu and Elizabeth S. Bowman, Editors Trauma and Sexuality: The Effects of Childhood Sexual, Physical, and Emotional Abuse on Sexual Identity and Behavior Haworth Medical Press Addressing a highly charged topic, the editors of this volume, James Chu, HMS associate professor of psychiatry at McLean Hospital, and Elizabeth Bowman of the Indiana University School of Medicine, aim to rectify the relative absence of discussion and knowledge in the area of trauma and sexuality. The authors of the seven chapters represent some of the most advanced thinking on sexuality as it relates to trauma. They provide insight and expertise to help clinicians look non-judgmentally at the profound effects of early abuse on the sexual identities, orientation, behaviors, and fantasies of people who come to them for help. David Frank, Editor Signal Transduction in Cancer Kluwer Academic Publishers Cancer often subverts the signaling pathways that help a normal cell interact appropriately with its environment. For example, mutations can activate signaling cascades leading to survival, proliferation, or blocked differentiation. Starting with the Trk family of receptor tyrosine kinases, the book groups the major areas of signaling research with particular importance to human cancer into four sections: receptors at the cell surface, intracellular signaling cascades, transcription factors' function in the nucleus, and pathways triggering programs of cell death. The fast-moving field holds promise for clinical therapy as scientific advances and medical practice rapidly converge. Nicholas L. Tilney Transplant: From Myth to Reality Yale University Press Nicholas Tilney's book traces the history of transplantation, from the ancient Greek fascination with satyrs and chimeras through modern clinical cases. The result is a trove of strange tales, including one about the use of a patient's forehead skin to create an artificial "nose" in 1000 B.C. and another about the transplant of a baboon's heart into Baby Fae in 1984. In the last several chapters, Tilney, the Francis D. Moore professor of surgery at Brigham and Women's Hospital, delves into the current ethical controversies surrounding donor payments, donor brain death, and xenotransplantation. James M. Ellison and Sumer Verma, Editors Depression in Later Life: A Multidisciplinary Psychiatric Approach Marcel Dekker Depression in the elderly is an underdiagnosed, undertreated, and debilitating mental illness with consequences of increased mortality from illness, excessive suffering, and suicide. The clinical situation is especially complicated, since most elderly have other illnesses or medications that could affect treatment. As part of a 24-book series on medical psychiatry, this volume by James Ellison, HMS associate clinical professor of psychiatry, and Sumer Verma, HMS lecturer on psychiatry, both at McLean Hospital, seeks to raise the awareness of medical practitioners on issues surrounding the elderly and depression. The book's 14 chapters are divided into an overview of depression in the elderly and therapeutic interventions and outcomes. Topics include diagnosing depression, bereavement and depression, caregiver depression, pharmacotherapy, and barriers and solutions to medical adherence. Lisa Iezzoni When Walking Fails: Mobility Problems of Adults with Chronic Conditions University of California Press About one in 10 adult Americans find their walking slowed by progressive chronic conditions like arthritis, accidental falls, heart and lung diseases, stroke, and diabetes. For Lisa Iezzoni, HMS professor of medicine at Beth Israel Deaconess Medical Center, it was multiple sclerosis that tripped her up walking to classes at HMS and finally drove her to a motorized scooter, although she can still walk short distances. Iezzoni does not practice medicine, but her interviews with 119 people and her compelling story may be therapeutic for people who have walking difficulties and for their families. She explains different kinds of mobility problems, reveals how walking difficulties affect daily life and relationships, offers strategies for improving mobility, discusses pros and cons of mobility aids, and tackles the problem of what health insurers will cover. Lisa Krivickas, Editor Electrodiagnostics in Neuromuscular Disorders Saunders Guest editor Lisa Krivickas, HMS assistant professor of physical medicine and rehabilitation at Spaulding Rehabilitation Hospital, calls a thorough electrodiagnostic evaluation a key component of a physical examination of most patients with neuromuscular disorders. More than half of this book discusses useful techniques, such as repetitive nerve conduction and exercise testing, single fiber electromyography, and transcranial magnetic stimulation. In the second section, authors summarize how the techniques fit into clinical evaluation of motor neuron disease, peripheral neuropathies, neuromuscular junction disorders, myopathies, and pediatric neuromuscular diseases. Kaethe Weingarten Common Shock: Witnessing Violence Every Day: How We Are Harmed, How We Can Heal Dutton/Penguin USA Kaethe Weingarten, HMS associate clinical professor of psychiatry at Cambridge Hospital, defines common shock as the biological and psychological responses of witnesses to violence. She examines the effects of observing violence--numbness and anger, memory loss, sadness, and shame--and explores the societal consequences. Addressing the full range of violence, from combat and terrorist attacks to domestic violence to gratuitous violence in entertainment, Weingarten offers tools to take action. These include managing symptoms of shock, coping with the suffering of the sick and dying, helping children who witness violence, and making a difference as an ordinary citizen. Mohammed Razzaque and Takashi Taguchi Renal Fibrosis Karger Mohammed Razzaque, instructor in oral medicine, infection, and immunity at HSDM, and Takashi Taguchi of Nagasaki University, present a synopsis of progress in the understanding of cellular and molecular mechanisms of fibrotic renal disease. Chapters discuss proteinuria and tubulointerstitial injury, roles and regulation of TGF-beta, chemokines, oxidant stress, matrix remodeling, significance of renal expression of NF-kappa, and the potential impact of cell death in renal fibrosis. The publication is intended for general health professionals in immunology and cell biology, as well as for clinicians and researchers in nephrology, pathology, and matrix biology. Susan Briggs and Kathryn Brinsfield, Editors Advanced Disaster Medical Response: A Manual for Providers Harvard Medical International Edited by Susan Briggs, HMS assistant professor of surgery at Massachusetts General Hospital, and Kathryn Brinsfield, associate medical director of Boston EMS, this manual is designed to train health care providers to respond to natural and man-made disasters, including those caused by weapons of mass destruction. Twenty-five chapters cover mass casualty incident management, incident command structure, and medical and public health response to disasters. Other topics include decontamination, medical response to terrorism, care of injuries in disasters, and environmental considerations. Gregory W. Randolph Surgery of the Thyroid and Parathyroid Glands Saunders Understanding and treating thyroid and parathyroid disease requires a multidisciplinary approach, considering the importance of the glands in the endocrine system and their location in the complex and delicate thoracic region. This comprehensive textbook, by Gregory Randolph, HMS assistant professor of otology and laryngology at the Massachusetts Eye and Ear Infirmary, satisfies this need by covering the latest in pathophysiology, surgical techniques, and technology related to the thyroid and parathyroid. As such, it is a valuable general reference for both experienced surgeons and surgeons in training. Every chapter is written by leading clinicians and researchers from otolaryngology, thoracic surgery, and general surgery, and the surgical chapters are complemented by detailed medical illustrations. Throughout the book, Randolph presents the field's controversies, with information on the advantages and disadvantages on both sides of the issues. Steven Weinberger Principles of Pulmonary Medicine, Fourth Edition Saunders This book by Steven Weinberger, HMS professor of medicine at Beth Israel Deaconess Medical Center, offers an integrated, user-friendly approach to pulmonary medicine. It introduces anatomic and physiologic concepts; shows how to recognize and evaluate patients with respiratory disease; and helps readers choose effective treatments. The fourth edition features the latest imaging and molecular diagnostic methods in pulmonary disease. It addresses lung disease in AIDS and its complications, pathogenesis and management of asthma and interstitial lung diseases, and management of respiratory failure. The book also includes high-quality images of radiographs, CT scans, and CT angiograms.