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RESOURCES Harvard Wins $10 M to Build Chemical Libraries, Techniques Harvard University through HMS has been awarded a $10 million Center of Excellence grant from the National Institute of General Medical Sciences (NIGMS) to establish the Harvard Center for Chemical Methodologies and Library Development (HCMLD). The center will enable a team of multidisciplinary researchers to explore new reactions for creating chemical diversity, invent new technologies to support chemical-library synthesis, and build new automated analysis systems. By sharing their results in a public, Web-accessible database, they hope to increase the understanding of the relationship between chemical and biological spaces, diminishing the gap between biology and medicine. The new center will be directed by Stuart Schreiber, chair of Harvard's Department of Chemistry and Chemical Biology and director of the Initiative in Chemical Genetics at the Institute of Chemistry and Cell Biology. The center will work collaboratively with several laboratories around the University, the ICCB, and the chemical gentics initiative (which was originally called the Molecular Target Lab.) "The HCMLD provides an extraordinary opportunity for chemists to contribute to the life sciences in ways that would not be possible otherwise. It recognizes the vital role that chemical synthesis plays in uncovering the principles that underlie biology and medicine," said Schreiber. The new center will be separate from the department and chemical genetics initiative, but the three facilities will benefit from their close association and will use common robotic facilities, currently located on the HMS Longwood campus. The Center of Excellence grant is the first grant to specifically support chemical discovery at the Initiative in Chemical Genetics. With the establishment of the HCMLD, the initiative's chemistry researchers will be able to redouble their efforts in the discovery of new chemical reactions and advancement of chemical technology platforms. The initiative will in turn have more compounds of greater structural diversity for collaborative biological screening.