Cell Biology: One-way Calcium Channel Pinpointed Within the Cell Neuroscience: Knocking Down Cell Cycle Protein Picks Up Axon Growth Microbiology: Early Step in Protein-folding Revealed by Bacterial Mutant Milestone Symposium 5 Hope, Caution Expressed About Stem Cells Milestone Symposium 4 Speakers Unmask Molecular Players in the Brain Dental Practice: Dentistry's Future Glimpsed at Leadership Forum Green Campus Initiative: Harvard's Longwood Schools Grow Greener Outreach: Medical Team Aids Earthquake Relief in Iran Second-year Show: Students Rollick Along the Low Road in Second-year Show New Books: The Winter Bookshelf   Protein-Protein Interactions Mapped for C. elegans Reading Expressions: A Skill Toward Becoming A Better Doctor? High Intake of Vitamin D Supplement May Cut Risk of Multiple Sclerosis Nuclear-export Inhibitors Found In Cell-based Screen   Appointments to Full Professor HSPH Awarded $20.5m Biodefense Grant Nominations Sought for Dean's Awards to Advance Women FDA Commissioner Speaks at Next Milestone Symposium HSPH Calls for Myrto Lefkopoulou Lecture Award Nominees News Brief Honors and Advances In Memoriam: David Bray James Roberts David Freiman William Montgomery   A Joke as Cover for Sexism and Violence   Medicare Drug Benefit May Unsettle Some Stomachs   Front Page

NEW BOOKS The Winter Bookshelf Recent Books by Faculty of Harvard Medical, Dental, and Public Health Schools Walter H. Abelmann, Editor The Harvard-MIT Division of Health Sciences and Technology: The First 25 Years 1970-1995 Harvard-MIT Division of Health Sciences and Technology This institutional biography traces the genesis of a unique collaboration between Harvard and MIT, the combined Division of Health Sciences and Technology. The HST program aimed to marry a Harvard education in biology and medicine with MIT's physical sciences and engineering in an early model of interdisciplinary research. Edited by Walter H. Abelmann, HMS professor emeritus of medicine at MIT, the volume contains chapters by HST founders from both institutions, offering personal accounts of the program's trials. Also included is an evaluation of HST with follow-up on the careers of its first 476 MD and PhD graduates. Tracy T. Batchelor, Editor Lymphoma of the Nervous System Butterworth-Heinemann This resource for physicians, edited by Tracy Batchelor, HMS assistant professor of neurology at Massachusetts General Hospital, contains contributions from 26 specialists. Starting with an overview for the nononcologist, the book quickly delves into the pathology, diagnosis, and treatment of primary central nervous system lymphoma (PCNSL). It then addresses the main neurological complications of lymphoid malignancies and finishes with a section on special topics, such as intraocular lymphoma. Because the incidence of PCNSL has jumped about threefold over the last two decades, according to the foreword by Stuart Grossman of Johns Hopkins University, the release of this book is especially well timed. Francoise Gray, Umberto De Girolami, and Jacques Poirier Escourolle & Poirier Manual of Basic Neuropathology, Fourth Edition Butterworth-Heinemann Previous versions of this classic text had only two editors. So great is the pace of discovery in neuropathology, however, that a third co-editor, Umberto De Girolami, HMS professor of pathology at Brigham and Women's Hospital, was recruited for the fourth edition. He and his two French colleagues, along with multiple experts, have produced a book that introduces the beginning student to the major hallmarks of neuropathology--tumors, trauma, infections, prion diseases, degenerative disorders, and congenital malformations--from the perspective of molecular genetics and cell biology as well as the more traditional routes of anatomy and pathology. Eric Leskowitz Complementary and Alternative Medicine in Rehabilitation Churchill Livingstone This volume is part of the Medical Guides to Complementary and Alternative Medicine series edited by Marc Micozzi of the University of Pennsylvania. Eric Leskowitz, staff psychiatrist in the pain management program at Spaulding Rehabilitation Hospital and clinical instructor in psychiatry at HMS, considers all levels of the human being as patient--body, mind, and spirit--in this practical guide to integrating alternative therapies into traditional rehabilitation treatment. Evidence-based clinically relevant techniques in four groups of therapy (body-oriented, mind/body, energy-based, and emergent approaches) are presented, along with a section detailing treatment for specific conditions. Richard Beaser and the Staff of Joslin Diabetes Center Joslin's Diabetes Deskbook: A Guide for Primary Care Providers, Revised Edition Joslin Diabetes Center This reference compiles the latest diabetes research from Joslin Diabetes Center. Richard Beaser, executive director of professional education at Joslin and HMS assistant clinical professor of medicine, covers a range of topics, including diagnosis, oral medications, insulin treatment programs, nutritional therapy and exercise, risk reduction, gender-specific issues, and patient education. The book examines the treatment of diabetes not as a single disease, but as several complex disorders sharing the common feature of elevated glucose levels in the blood. Donald M. Berwick Escape Fire: Designs for the Future of Health Care Jossey-Bass Donald Berwick, president, CEO, and cofounder of the Institute for Healthcare Improvement (IHI), has collected the 11 speeches he delivered at the IHI's annual National Forum on Quality Improvement in Health Care from 1992 to 2002. In his colorful talks like "Sauerkraut, Sobriety, and the Spread of Change," he argues that the U.S. health care system is in need of an overhaul and a revolutionary redesign. In an eight-step plan, Berwick, a clinical professor of pediatrics and health care policy in the Department of Pediatrics at Children's Hospital and HMS, outlines his suggestions about how to recreate the health care system with the patient as its focus. Barry Brenner, Editor Brenner & Rector's The Kidney, Seventh Edition Saunders At nearly 3,000 pages, this expanded two-volume set can assert its authority in nephrology by sheer weight alone. In his preface, editor Barry Brenner, the Samuel A. Levine professor of medicine at Brigham and Women's Hospital, notes the growth of fundamental knowledge in nephrology, such as discoveries of atomic structures of ion channels, and diagnosis, such as genotyping for polycystic kidney disease. Still, scientists and doctors remain outpaced by the increase in patients with kidney failure, predicted to soar with the growth in diabetes. Prevention has moved to the front of the agenda, especially since questions remain about the quality and adequacy of dialysis and availability of organs for transplantation. John R. Peteet Doing the Right Thing: An Approach to Moral Issues in Mental Health Treatment American Psychiatric Publishing When someone is under psychiatric care, his moral values may eventually come into consideration due to their interaction with the patient's mental-health issues. The moral dilemmas that may ensue--for example, is it right to seek a divorce?--are the focus of this book by John Peteet, HMS associate professor of psychiatry at Brigham and Women's Hospital. The author's research from the past two decades is the basis of a series of flow charts that provide an "adequate framework" for considering moral issues that arise from treatment. The narrative provides a clear, practical read for both the clinician and layperson. Phyllis L. Carr, Hope A. Ricciotti, Karen M. Freund, and Scott Kahan In a Page: OB/GYN & Women's Health Blackwell Publishing The succinct disease-per-page format of this book aims to save time for doctors on busy wards by summing up key information about the 126 most commonly encountered diseases, disorders, and medical issues. The authors, including Hope Ricciotti, an HMS assistant professor of obstetrics, gynecology and reproductive biology at Beth Israel Deaconess Medical Center, have organized each page into sections covering etiology and pathophysiology, differential diagnosis, presentation, diagnosis and evaluation, treatment, and prognosis and complications. Subjects range from well care of female adolescents to cancer in pregnancy to stroke. Targeted to medical students and residents, the book may be used for independent study, as a quick reference on rounds, or as a board review tool. James M. Donovan Short-term Object Relations Couples Therapy: The Five-Step Model Brunner-Routledge James Donovan, HMS assistant clinical professor of psychology and a staff psychologist at Harvard Vanguard Medical Associates for 30 years, has written a practical guide for clinicians who want to pursue couples work. In object relations therapy, members of a couple can expand their insight by learning that their problems with each other are due in part to unfinished business from their own families and the "internal objects"--mental images of self and others--that remain as a result. Donovan, who devotes half his practice to couples therapy, uses clinical vignettes to illustrate the tools he has developed for short-term object relations therapy. Richard Geist Investor Therapy Crown Business Billed as a psychologist and investing guru, Richard Geist, a clinical instructor in psychology in the Department of Psychiatry at the Massachusetts Mental Health Center, offers advice that seeks to make individuals aware of the emotions that underlie their investing. The complete investor not only has to know the technical aspects of the market, he says, but also the personal feelings wrapped up in buying and selling. Geared toward both the professional and nonprofessional, the book suggests that investors develop a personal psychological framework to guide their decisions. Robert D. Odze, John R. Goldblum, and James M. Crawford, Editors Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas Saunders Written for general pathologists and pathologists in training, this volume is the first complete and comprehensive text on pathologies of the gastrointestinal tract, biliary tract, liver, and pancreas, according to Robert Odze and his fellow editors. Odze is an HMS associate professor of pathology at Brigham and Women's Hospital. All 59 contributors to the book are pathologists with special expertise in the areas they have covered. Their discussions are based on morphology, with particular emphasis on histologic methods that may be useful in differentiating diseases. Steven D. Pearson, James E. Sabin, and Ezekiel J. Emanuel No Margin, No Mission: Health-Care Organizations and the Quest for Ethical Excellence Oxford University Press "Tell us about the problems that keep you up at night," was one of the questions asked of leaders in health-care organizations taking part in a project called "Best Ethical STrategies" (BEST). The query began to uncover the most important ethical dilemmas confronted by these organizations as they seek to deliver ethical care in a competitive market. The book, whose authors include Steven Pearson, HMS associate professor of ambulatory care and prevention at Harvard Pilgrim Health Care, and James Sabin, HMS clinical professor of psychiatry and director of the Center for Ethics and Managed Care at HMS, presents the results of the two-year national BEST project. Deborah Prothrow-Stith and Howard R. Spivak Murder is No Accident: Understanding and Preventing Youth Violence in America Jossey-Bass Publishers Boston has become a model of youth violence prevention, and the authors of this book, Deborah Prothrow-Stith, HSPH associate dean and professor of public health practice, and Howard R. Spivak of Tufts University School of Medicine helped lead the city's progress. They have geared this book to community leaders interested in replicating that success. "In this book we provide you with the same information so that you too can go out and build the connections and create the process that will work in your community," the authors write, stressing that connections are necessary in forming an effective critical mass of programs and people. Marc J. Roberts, William Hsiao, Peter Berman, and Michael R. Reich Getting Health Reform Right: A Guide to Improving Performance and Equity Oxford University Press This text provides a roadmap through each stage of the health-reform cycle and arenas in which government can improve health-system performance, with special attention to the equity of these results. The HSPH authors are Department of Health Policy and Management faculty members Marc Roberts, professor of political economy and health policy, and William Hsiao, the K.T. Li professor of economics, and Department of Population and International Health faculty members Peter Berman, professor of population and international health economics, and Michael Reich, the Taro Takemi professor of international health. They draw on their academic research, their years of courses and seminars for health-sector decision-makers around the world, and their work with various governments. T. Berry Brazelton and Joshua D. Sparrow Feeding: The Brazelton Way and Toilet Training: The Brazelton Way Da Capo Press Berry Brazelton, founder of the Child Development Unit at Children's Hospital and clinical professor emeritus of pediatrics at HMS, and his co-author Joshua Sparrow, HMS assistant professor of psychiatry at Children's, continue "The Brazelton Way" series of child-rearing books based on Brazelton's "Touchpoints" approach: watch for the setbacks that precede a step of progress. In Feeding, the authors address basic nutritional needs, table manners, and the roots of eating disorders. Toilet Training gives advice for each stage of the early years, emphasizing that the child's motivation is the key to success. Steven Schachter, Editor Visions: Artists Living with Epilepsy Academic Press This book, edited by Steven Schachter, HMS professor of neurology at Beth Israel Deaconess Medical Center, adds 35 more names to the list of artists who had seizures. One of the main symptoms of epilepsy, seizures also affected Leonardo da Vinci, Michelangelo, and Vincent van Gogh. A striking and diverse range of styles and media are accompanied by brief and compelling personal statements by the artists about their epilepsy and work. "Epilepsy is not the negative demon I once thought it was, but a condition that carries no shame or embarrassment," said one artist, whose twin suffered severe brain damage from years of crushing his skull against the floor during seizures. All proceeds from book sales benefit the work of the Epilepsy Foundation. Lauren Slater, Jessica Henderson Daniel, and Amy Elizabeth Banks, Editors The Complete Guide to Mental Health for Women Beacon Press The purpose of this guide, according to the editors, is to present a model of female psychological development to supplement the current models that are largely based on men. The themes of the book are life stages, life issues, and social contexts for mental health, with the section on life issues being subdivided into discussions of sexuality, relationships, and traumatic experiences. Jessica Daniel, HMS assistant professor of psychology in the Department of Psychiatry at Judge Baker Children's Center, and her co-editors gear the text toward a broad audience, establishing a supportive, trustworthy tone in addressing the reader directly in the second person. The many contributors to the book represent a wide range of backgrounds and diverse points of view.