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Cell Biology:
One-way Calcium Channel Pinpointed Within the Cell
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Neuroscience: Knocking Down Cell Cycle Protein Picks Up Axon Growth
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Microbiology: Early Step in Protein-folding Revealed by Bacterial Mutant
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Milestone Symposium 5 Hope, Caution Expressed About Stem Cells
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Milestone Symposium 4 Speakers Unmask Molecular Players in the Brain
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Dental Practice: Dentistry's Future Glimpsed at Leadership Forum
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Green Campus Initiative: Harvard's Longwood Schools Grow Greener
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Outreach: Medical Team Aids Earthquake Relief in Iran
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Second-year Show: Students Rollick Along the Low Road in Second-year Show
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New Books: The Winter Bookshelf
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Protein-Protein Interactions Mapped for C. elegans
Reading Expressions: A Skill Toward Becoming A Better Doctor?
High Intake of Vitamin D Supplement May Cut Risk of Multiple Sclerosis
Nuclear-export Inhibitors Found In Cell-based Screen
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Appointments to Full Professor
HSPH Awarded $20.5m Biodefense Grant
Nominations Sought for Dean's Awards to Advance Women
FDA Commissioner Speaks at Next Milestone Symposium
HSPH Calls for Myrto Lefkopoulou Lecture Award Nominees
News Brief
Honors and Advances
In Memoriam:
David Bray
James Roberts
David Freiman
William Montgomery
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 A Joke as Cover for Sexism and Violence
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 Medicare Drug Benefit May Unsettle Some Stomachs
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Front
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BULLETIN
Appointments to Full Professor
These faculty members were appointed to a full professorship in December.
Paul Anderson
Professor of Medicine
Brigham and Women's Hospital
Anderson is the associate chief of the Division of Rheumatology, Immunology and Allergy at BWH. His research focuses on post-transcriptional mechanisms that regulate the production of pro-inflammatory proteins involved in the pathogenesis of immune-
mediated inflammatory disease. He has shown that mutant mice lacking these regulatory programs develop spontaneous inflammatory arthritis. Studies of these animal models could lead to the development of new drugs for patients with rheumatoid arthritis.
Gary Gilliland
Professor of Medicine
Brigham and Women's Hospital
Gilliland is interested in the genetics of human leukemias with a focus on translating findings into improvements in therapy for lethal malignancies. His lab utilizes positional cloning strategies to identify genes causally implicated in pathogenesis of leukemia, to characterize the transforming properties of these mutant genes in cell culture and murine models of leukemia, to develop and test inhibitors of the genes in these systems, and to bring promising agents forward into phase I and II clinical trials. Gilliland is also an associate Howard Hughes investigator, director of the leukemia program for the Dana-Farber Harvard Cancer Center, and a Doris Duke distinguished clinical scientist.
Charles Hatem
Professor of Medicine
Beth Israel Deaconess Medical Center
Hatem has been a primary care physician at Mount Auburn Hospital since 1971, where he also serves as the director of medical education. He is the director of the Rabkin Fellowship in Medical Education at the Shapiro Center at BID. His educational work has focused on the application of adult learning perspectives into curricula and teaching strategies for students, house staff, fellows, and faculty.
Jae Jung
Professor of Microbiology and Molecular Genetics
New England Primate Research Center
Research in Jung's laboratory is focused principally on understanding the molecular mechanisms of lymphoproliferative diseases induced by the gamma-2 herpesviruses and on developing animal models for human diseases. The gamma-2 herpesviruses include murine herpesvirus 68, herpesvirus saimiri, rhesus monkey rhadinovirus, and Kaposi's sarcoma-associated herpesvirus. Jung is also chair of the Virology Division of the New England Primate Research Center.
Christopher Murray
Professor of Social Medicine
Harvard Medical School
Murray is also director of the Harvard University Global Health Initiative and at HSPH is the Richard B. Saltonstall professor of public policy and a professor of international health economics in the Department of Population and International Health. His recent work includes developing new approaches to the measurement
of population health, to cost-effectiveness analysis, and to the conceptualization, measurement, and national application of health systems performance assessment.
Sharon-Lise Normand
Professor of Health Care Policy (Biostatistics)
Department of Health Care Policy
Harvard Medical School
Normand is also a professor in the Department of Biostatistics at HSPH. Her research focuses on the development of statistical methods for health services research, primarily using Bayesian approaches to problem-solving, including quality-of-care assessment, provider-
profiling, causal inference, hierarchical modeling, and latent variable analyses. She is director of Mass-DAC, the data-coordinating center responsible for collecting, analyzing, and reporting on the quality of all cardiac surgeries and cardiac interventions in Massachusetts. She is a fellow of the American Statistical Association and of the American College of Cardiology.
Steven Shoelson
Professor of Medicine
Joslin Diabetes Center
Shoelson's laboratory has identified the inflammatory NF-kappa B pathway in fat and liver as a key molecular connection between obesity and insulin resistance. His studies use this information to further investigate the pathogenesis of insulin resistance and to develop pharmacological interventions. Shoelson is Joslin's Helen and Morton Adler chair and section head of Cellular and Molecular Physiology as well as associate research director.
HSPH Awarded $20.5m Biodefense Grant
The federal government has awarded HSPH a $20.5 million biodefense grant to study the immune system response to pathogens. The four-and-a-half-year grant from the National Institute for Allergy and Infectious Diseases will be led by Laurie Glimcher, the Irene Heinz Given professor of immunology in the Department of Immunology and Infectious Diseases. HSPH dean Barry Bloom said, "The School is gratified to receive this award, which will aid in global understanding of the immune system response to attack by infectious agents, whether naturally occurring or intentional. Our national security depends increasingly on vigorous basic research and a strong public health infrastructure to protect public health at all times."
Nominations Sought For Dean's Awards
to Advance Women
The Dean's Award for Leadership in the Advancement of Women Faculty seeks nominations of faculty members committed to the recruitment, retention, and advancement of women at HMS and HSDM. Faculty members of either gender serving within HMS or HSDM are eligible, excluding those with positions in faculty development or an office for women's careers. Nominations, which must come from voting faculty, are due by Thursday, Feb. 26. The dean also has an award recognizing leadership in the advancement of women staff, open to any member of the HMS community. Nominations for this award must come from staff members and are due by Friday, March 5. Visit www.hms.harvard.edu/jcsw for more information.
FDA Commissioner Speaks at Next Milestone Symposium
The sixth HMS Milestone event celebrating the School's new research building and the 100th anniversary of the groundbreaking for the Longwood Quadrangle will be held March 9 from 3:00 to 5:00 p.m. in the new research building amphitheater. The Department of Health Care Policy presents a program titled, "Moving Drugs Forward: Reaching the Patient." Mark
McClellan, commissioner of the Food and Drug Administration, is the keynote speaker. Online registration is required; to register or for more information, visit www.hms.harvard.edu/milestone.
HSPH Calls for Myrto Lefkopoulou Lecture Award Nominees
The Myrto Lefkopoulou Distinguished Lecture at HSPH seeks nominations for the 2004 award. The lectureship is given to a biostatistical student who has contributed to excellence in teaching biostatistics or to collaborative or methodologic research in the applications of statistical methods to biology or medicine. The lectureship is ordinarily given to an individual within 15 years of earning a doctorate. The program takes its name from Myrto Lefkopoulou, a faculty member and student in the Department of Biostatistics who died of cancer in 1992 at the age of 34. Nominations must include a letter of nomination and CV and should be sent to the Myrto Lefkopoulou Lecture Committee, Department of Biostatistics, HSPH, 655 Huntington Ave., Boston, MA 02115. The deadline for submissions is March 15.
News Brief
The HMS Center for Health and the Global Environment organized a briefing for the U.S. House of Representatives and Senate on the environmental stresses the world's oceans are facing. According to a white paper the center issued, global warming and changes in coastal marine ecosystems are resulting in loss of aquatic life and dangers to human health. Paul Epstein, associate director of the center and HMS instructor in medicine at Massachusetts General Hospital, said, "The changes we are seeing now are having profound impacts on our health and the livelihoods of many communities."
Honors and Advances
Emil Frei III, Dana-Farber Cancer Institute physician-in-chief emeritus, has been selected to receive the 2003 Pollin Prize in Pediatric Research. The award recognizes his contribution to advancements in treatment of acute lymphoblastic leukemia, the most common form of pediatric cancer. Funded by the Linda and Kenneth Pollin Foundation and administered by New York-Presbyterian Hospital, the prize includes a $100,000 award.
Edwin Mikkelsen, HMS associate professor of psychiatry at McLean Hospital, was presented with the Frank J. Menolascino Award in recognition of clinical, research, and educational contributions to understanding psychiatric disorders in individuals with mental retardation. Mikkelsen's primary research interest has been the development of psychopharmacological algorithms for the treatment of psychiatric disorders in individuals with developmental disabilities.
Coleen Sabatini has been chosen for the 2003 Hollis Albright Award, which honors and encourages an outstanding HMS student. Sabatini is currently a fifth-year medical student at both HMS and HSPH and is applying for residency programs in orthopedic surgery.
The American College of Psychiatrists has awarded Laughlin Fellowships to Dost Ongur of Massachusetts General Hospital and McLean Hospital and James Herrera of the Harvard Longwood Psychiatry Residency Training Program. The fellowships recognize residents who have excelled in research, clinical care, program development, and community service.
The 2003 Hoogstraal Award for outstanding lifelong service to medical entomology has been given to Andrew Spielman, HSPH professor of tropical public health in the Department of Immunology and Infectious Diseases. He has published in medical entomology for more than 50 years and authored more than 350 publications.
Michael Greenberg, HMS professor of neurology and of neurobiology and both the Kirby director of neuroscience and the director of the Division of Neuroscience at Children's, was recognized with a McKnight Award for his research exploring new approaches to diagnosing, preventing, and treating injuries or diseases affecting the brain and spinal cord. Greenberg was honored for his project, "A Role for MeCP2 in Activity-dependent Regulation of Gene Expression and Rett syndrome." The award, given by the McKnight Endowment Fund for Neuroscience, includes a $300,000 grant over three years.
A paper co-authored by Myron Spector, professor of orthopedic surgery (biomaterials) and director of orthopedic research at Brigham and Women's Hospital, was selected for the 2004 John Charnley Award from the Hip Society. The manuscript, "The Role of Joint Fluid in the Tribology of Total Joint Arthroplasty," was written with Dan Mazzucco and describes the findings from Mazzucco's HST doctoral thesis work, completed in July 2003. The Charnley Award recognizes innovative research encompassing important advances in the management of hip disorders.
In Memoriam
David Bray, former executive dean of administration at HMS, died Jan. 18 at age 62.
Bray retired in 1999 after nearly 20 years at HMS and is remembered as an innovative strategic planner. He helped develop and launch Harvard Medical International and oversaw administrative planning for HMS's $300 million campuswide facilities modernization program, the recruitment of leadership in the science departments, the transformation of the medical curriculum into a model for the country, and the establishment of the Department of Health Care Policy.
Bray's interest in public policy grew from his government experience in the 1960s and 1970s when he worked in Washington, D.C., as a deputy associate director in the Office of Management and Budget and as an economic affairs assistant to the director of the Central Intelligence Agency. Before coming to HMS in 1982, he was a senior executive at the University of Chicago Medical Center.
After his retirement, Bray continued to serve on several boards, including Shorebank Corp., a community development and environmental bank, and Green Mountain College in Vermont. He was a founding member of the Giving Back Fund, a charitable foundation that assists celebrities in leveraging their fame on behalf of philanthropy, and was on the scientific advisory board for its Cure Parkinson's program.
Bray is survived by his wife, Louise; his son, Andrew; his daughter, Louisa Creamer; and one grandson. (Photo by Joe Demb)
James Roberts, HMS assistant professor of anesthesia at Massachusetts General Hospital, passed away Dec. 25 at age 66.
Roberts received his bachelor's degree from DePauw University in Greencastle, Ind., in 1959 and his master's degree from Indiana University in 1962. In 1966, he received his MD from the University of Cincinnati. After an internship in medicine at Chicago's Cook County Hospital, Roberts was a lieutenant commander in the U.S. Navy from 1967 to 1969.
He began his residency at MGH in 1969 and joined the HMS faculty as instructor in anesthesia in 1973. He became an assistant professor of anesthesia in 1985. Roberts's research interests included clinical management of the airway, flexible fiberoptic laryngoscopy, and malignant hyperthermia.
Roberts is survived by his wife, Charlene; his four children, James Roberts Jr., Teresa Feher, Laura Umphrey, and Mary London; and three grandchildren.
David Freiman, former pathologist-in-chief at Beth Israel Hospital and the Mallinckrodt professor emeritus of pathology, died Dec. 10. He was 92.
Freiman was the husband of Ruth (Schein) Freiman, the medical center's archivist, who has been a volunteer and employee for more than 40 years.
A native of New York City, Freiman graduated from Long Island College of Medicine, now SUNY-Downstate. He trained at Brooklyn's Jewish Hospital, Kingston Avenue Hospital for Contagious Diseases, and Montefiore Hospital before joining Massachusetts General Hospital in 1944 as an assistant pathologist.
In 1956, he became pathologist-in-chief at Beth Israel and served until his retirement in 1979. During his tenure, the pathology laboratory merged with the clinical laboratories and blood bank, and the department grew into what is now a nationally recognized training and diagnostic center.
In 1969, Freiman was appointed the Mallinckrodt professor of pathology, the first chair endowed through HMS at Beth Israel. He was instrumental in the curriculum reorganization during the 1960s and 1970s, focusing on giving students options for course requirements so they could pursue individual interests.
Following his retirement, Freiman worked as a special assistant to Mitchell Rabkin, former president of Beth Israel, coordinating efforts to allocate space for clinical and research programs.
Freiman authored more than 60 papers on aspects of heart, blood vessel, and lung pathology and was well known for his contributions to the pathology of blood clotting and for his studies of sarcoidosis.
In addition to his wife, Freiman is survived by his daughter, Nancy; his son, Leonard; and three grandchildren.
William Montgomery, the John W. Merriam professor of otology and laryngology at the Massachusetts Eye and Ear Infirmary, died on Nov. 7, 2003. He was 80 years old.
Montgomery received his AB from Middlebury College in 1944 and his MD from the University of Vermont in 1947. During the Korean War, he served as a battalion surgeon for the U.S. Navy from 1950 to 1952, which he later recounted in his 1995 memoir, The Mustache that Walks Like a Man. He was awarded a Purple Heart and a Bronze Star with Valor.
From 1952 to 1955, Montgomery was an otolaryngology resident at HMS and MEEI. He was appointed professor of otology and laryngology in 1970 and named the John W. Merriam professor of otology and laryngology in 1993.
Montgomery was the author of more than 180 publications, the most influential of which was Surgery of the Upper Respiratory System, which saw three editions. He popularized osteoplastic frontal sinus obliteration in general otolaryngology, and in laryngology, he contributed to the understanding of cricoarytenoid arthritis and the management of chronic aspiration and thyroplasty.
Montgomery served as president of the New England Otolaryngological Society and received the Harris P. Mosher Memorial Award from the Triological Society and a 1984 Presidential Citation from the American Academy of Otolaryngology-Head and Neck Surgery. He was awarded the Newcombe Award from the American Laryngologic Association in 1990 and the 1991 Chevalier Jackson Award from the American Bronchoesophagologic Society.
Montgomery is survived by his sister, Jane; his sons, Lynn, Scott, Stuart, Leslie, and Robert; and seven grandchildren. Memorial gifts may be made to the William Montgomery Fellowship Fund at MEEI.
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