Neuroscience
Blocking Protein Might Reverse Hearing Loss

Cell Biology
Functional Protein Changes Caught and Quantified

Genomics
Gain and Loss of Amino Acids Detected Across All of Life

Ambulatory Care
A Third of Older People May Take Potentially Inappropriate Medicines

Social Medicine
Past Research Enables Mental Health Services to Fill Gap for Tsunami Survivors

New Books
The Winter Bookshelf

Bacteria Exhibit Novel Method for Sensing Environment

Enzymes Used to Generate Diversity in Antibiotics

Thalamus Calcium Channel Supports a Sound Sleep

New Appointments to Full Professorships

Ten Students Named Schweitzer Fellows

Red Book Grants List to Be Posted Next Week

Congratulations to Training Institute Grads

Honors and Advances

Failing Elders Weigh Heavily on Reservation Families

Some Wrinkles of Delayed Residency

Front Page

The Winter Bookshelf

Recent Books by Faculty of Harvard Medical, Dental, and Public Health Schools

William S. Appleton
The New Antidepressants and Antianxieties: What You Need to Know About Zoloft, Paxil, Wellbutrin, Effexor, Clonazepam, Ambien, and More, Third Edition
Plume
In his guide to antidepressants, William Appleton outlines the types of treatment used to combat clinical depression and discusses the pros and cons of each one. This latest edition details treatments used for depressive symptoms, such as insomnia or pain, in addition to standard antidepressive approaches. The book also includes chapters on rage and anxiety disorders. Appleton, an HMS assistant professor of psychiatry at the Massachusetts Mental Health Center, gives his readers the latest information on side effects, new and forthcoming medications, the interactions between therapy and drugs, herbal medicines, and how and when to stop taking a medication.

Julie M. Lamb, Marcy Levy, and Michael R. Reich
Wounds of War
Harvard Center for Population and Development Studies
Using striking photographs and charts to frame their observations, the editors of this handbook describe the effects of armed violence on populations around the world. Julie Lamb, a graduate student at HSPH; Marcy Levy, a recent HSPH graduate; and Michael Reich, director of the Harvard Center for Population and Development Studies, divided their book into three sections. The first deals with major themes in armed conflict, the second summarizes ten current conflicts, and the third is a timeline of milestones in the recent history of women and peace. The book was produced for the International Conference on Women Defending Peace.

Hari Garg and Charles Hales, Editors
Chemistry and Biology of Hyaluronan
Elsevier
The big sugar molecule hyaluronan promotes wound healing, mixes with water to make the synovial fluid that supports healthy joints, and helps lubricate the passage of both sperm and egg. Also active in disease, the normally low levels of hyaluronan circulating through the body can increase dramatically under certain pathological conditions, such as rheumatoid arthritis, liver cirrhosis, and ovarian cancer. Hari Garg, HMS principal associate in medicine, and Charles Hales, HMS professor of medicine, both at Massachusetts General Hospital, have edited “a detailed panoramic review of the chemistry and biology of hyaluronan.” Designed to reach the wider research community, 27 chapters cover the chemistry, biology, and potential therapeutic uses of hyaluronidases.

JoAnn E. Manson, Julie E. Buring, Paul M. Ridker, J. Michael Gaziano
Clinical Trials in Heart Disease, Second Edition
Elsevier Saunders
The recent discovery of cardiovascular risks associated with hormone replacement therapy have underscored the importance of large-scale clinical trials to assess treatments. Clinical Trials in Heart Disease, a companion text to Braunwald’s Heart Disease for clinicians and researchers, reviews the methodologies, pitfalls, and interpretation of clinical trials and details current progress of treatment trials for conditions associated with cardiovascular disease. The text has been extensively updated with several new chapters and information, reflecting the explosion of new trials since the first edition was published in 1999. The book brings together HMS faculty members JoAnn Manson and Elizabeth Brigham, professor of women’s health and professor of medicine; Julie Buring, professor of ambulatory care and prevention; Paul Ridker, the Eugene Braunwald professor of medicine; and J. Michael Gaziano, associate professor of medicine, all at Brigham and Women’s Hospital.

Dade W. Moeller
Environmental Health, Third Edition
Harvard University Press
Environmental Health offers a succinct but comprehensive introduction to environmental problems and their impact on human health. The book includes subject-by-subject evaluations of some of the major dangers that threaten us, from insects to radiation to sewage. It also helps define environmental health for the nonspecialist and discusses techniques of the field such as risk assessment, standards, monitoring, and environmental law. Widely used as a textbook in public health curricula, this newest edition updates information and includes timely topics like environmental economics, terrorism, and environmental justice. In each case, Dade Moeller, HSPH professor emeritus of engineering in environmental health, advocates a systems approach to evaluating and solving environmental problems.

Brian J.G. Pereira, Mohamed H. Sayegh, Peter Blake
Chronic Kidney Disease, Dialysis, and Transplantation, Second Edition
Elsevier Saunders
The authors address the underlying physiology and the clinical responses to chronic kidney disease over almost 900 pages. Ninety-six contributors allow thorough coverage, with chapters on sleep disorders in chronic kidney disease, transplant donor and recipient evaluation, and the economic cost of caring for those with kidney disease. In this second edition, there are new sections on chronic kidney disease and its complications and on acute renal failure. The editors maintain an emphasis on practical details throughout, giving advice on choosing the right dialysis catheter and pointing out the most common errors in the disinfection of dialysis machines. Co-author Mohamed Sayegh is an HMS professor of medicine at Brigham and Women’s Hospital, and 13 of the contributors are associated with Harvard schools.

Howard L. Weiner
Curing MS: How Science Is Solving the Mysteries of Multiple Sclerosis
Crown Publishers
Almost half a million Americans have multiple sclerosis, and until recently, there were no treatments to slow the progress of the disease. Howard Weiner, the Robert L. Kroc professor of neurology at Brigham and Women’s Hospital and founder of the Partners MS Center, has investigated treatments for more than 25 years. In this book, he discusses the aspects of the disease that have been revealed during this period, and he recounts both his experiences with patients and his clinical research. Although geared to a lay audience, Weiner does not shy away from giving background on how science progresses, and the scientific reader will find his account engaging and compelling.

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