Focus
February 20, 2009

Martin TeicherPSYCHIATRY: Cutting Words May Scar Young Brains
Parents who ridicule, humiliate, or belittle their children may be causing them serious and permanent brain damage. New research from Martin Teicher and colleagues, published in the Feb. 1 issue of Biological Psychiatry, pinpoints this damage by applying an imaging technique that maps the fiber pathways in the brain. The images suggest that verbal abuse damages neural pathways in regions responsible for regulating emotions and processing language. Though parental verbal abuse has only recently been recognized as harmful, evidence is mounting that it may be as injurious as forms of abuse previously thought to be more severe.

S.V. SubramanianPUBLIC HEALTH: New Look at Classic Study Shows Overemphasis on Individual-level Data
A lot of what we know about what makes us sick and what keeps us well comes from following large groups of individuals over time. These studies reveal telling associations between disease and individual characteristics, such as diet, smoking, exercise and genes. But where people live also matters—and sometimes may matter more than who they are, according to S.V. Subramanian and his co-authors in a paper published online Jan. 28 in the International Journal of Epidemiology. The study revisits the profoundly influential statistics paper at the root of the big epidemiological datasets that populate 21st century science.

Larry Seidman and Anthony GiulianoPATHOLOGY: Pattern of Brain Activity Signals Danger of Schizophrenia
Motivated by the hope that they can pull people back from the brink of schizophrenia, Larry Seidman (right), Anthony Giuliano, and colleagues have been studying the earliest stage of schizophrenia, the prodromal phase. Seidman, along with Heidi Thermenos, and colleagues have gone back even earlier and are looking at the brains of people who do not display symptoms but are at high risk for the disease. They have found that a constellation of brain regions involved in self-reflection is unusually active in people with schizophrenia and, to a lesser extent, in those at risk for the disease. The findings appear in the Jan. 27 Proceedings of the National Academy of Sciences.

Copyright 2009 by the President and Fellows of Harvard College